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Eukaryotic viruses in the faecal virome at the onset of type 1 diabetes: a study from four geographically distant African and Asian countries

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F21%3A10426105" target="_blank" >RIV/00216208:11130/21:10426105 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064203:_____/21:10426105

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KydxIbI3RQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KydxIbI3RQ</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/pedi.13207" target="_blank" >10.1111/pedi.13207</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Eukaryotic viruses in the faecal virome at the onset of type 1 diabetes: a study from four geographically distant African and Asian countries

  • Popis výsledku v původním jazyce

    Studies of the faecal virome in type 1 diabetes (T1D) have been limited to populations of Europe and the USA. We therefore sought to characterize the stool virome in children after onset of T1D and in matched control subjects from four geographically distant African and Asian countries. Samples of stool were collected from 73 children and adolescents shortly after T1D onset (Azerbaijan 19, Jordan 20, Nigeria 14, Sudan 20) and 105 matched control subjects of similar age and locale. Metagenomic sequencing of the DNA and RNA virome was performed, and virus positivity was defined as more than 0.001% of reads of the sample. Selected viruses were also quantified using real-time PCR. Conditional logistic regression was used to model associations with eukaryotic virus positivity. Signals of 387 different viral species were detected; at least one eukaryotic virus was detected in 71% case and 65% control samples. Neither of observed eukaryotic virus species or genera differed in frequency between children with T1D and controls. There was a suggestive association of the total count of different viral genera per sample between cases (1.45 genera) and controls (1.10 genera, OR 1.24, 95%CI 0.98-1.57), and an unplanned subanalysis suggested marginally more frequent endogenous retrovirus signal in cases (in 28.8% vs. in 8.6% controls, OR = 4.55, 95%CI 1.72-12). No clear and consistent association with T1D was observed in the faecal viromes from four distant non-European populations. The finding of borderline associations of human endogenous retroviruses merits further exploration. This article is protected by copyright. All rights reserved.

  • Název v anglickém jazyce

    Eukaryotic viruses in the faecal virome at the onset of type 1 diabetes: a study from four geographically distant African and Asian countries

  • Popis výsledku anglicky

    Studies of the faecal virome in type 1 diabetes (T1D) have been limited to populations of Europe and the USA. We therefore sought to characterize the stool virome in children after onset of T1D and in matched control subjects from four geographically distant African and Asian countries. Samples of stool were collected from 73 children and adolescents shortly after T1D onset (Azerbaijan 19, Jordan 20, Nigeria 14, Sudan 20) and 105 matched control subjects of similar age and locale. Metagenomic sequencing of the DNA and RNA virome was performed, and virus positivity was defined as more than 0.001% of reads of the sample. Selected viruses were also quantified using real-time PCR. Conditional logistic regression was used to model associations with eukaryotic virus positivity. Signals of 387 different viral species were detected; at least one eukaryotic virus was detected in 71% case and 65% control samples. Neither of observed eukaryotic virus species or genera differed in frequency between children with T1D and controls. There was a suggestive association of the total count of different viral genera per sample between cases (1.45 genera) and controls (1.10 genera, OR 1.24, 95%CI 0.98-1.57), and an unplanned subanalysis suggested marginally more frequent endogenous retrovirus signal in cases (in 28.8% vs. in 8.6% controls, OR = 4.55, 95%CI 1.72-12). No clear and consistent association with T1D was observed in the faecal viromes from four distant non-European populations. The finding of borderline associations of human endogenous retroviruses merits further exploration. This article is protected by copyright. All rights reserved.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NV15-31426A" target="_blank" >NV15-31426A: Dětský diabetes v subsaharské Africe: genetické a virologické nálezy a jejich srovnání s evropskými populacemi</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Pediatric Diabetes

  • ISSN

    1399-543X

  • e-ISSN

  • Svazek periodika

    22

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    9

  • Strana od-do

    558-566

  • Kód UT WoS článku

    000637511300001

  • EID výsledku v databázi Scopus

    2-s2.0-85103632006