Primary Cutaneous CD8+Small-to Medium-Sized Lymphoproliferative Disorder in Extrafacial Sites: Clinicopathologic Features and Concept on Their Classification

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10138931" target="_blank" >RIV/00216208:11140/13:10138931 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/DAD.0b013e31825c3a33" target="_blank" >http://dx.doi.org/10.1097/DAD.0b013e31825c3a33</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/DAD.0b013e31825c3a33" target="_blank" >10.1097/DAD.0b013e31825c3a33</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Primary Cutaneous CD8+Small-to Medium-Sized Lymphoproliferative Disorder in Extrafacial Sites: Clinicopathologic Features and Concept on Their Classification

Popis výsledku v původním jazyce

Three cases with CD8+ small- to medium-sized lymphoproliferations in the skin at extrafacial sites are described. Clinically, the patients presented with papulonodular or plaque-like lesions without preceding patches. Histopathologically, nonepidermotropic nodular or diffuse infiltrates were composed of small-to medium-sized pleomorphic lymphocytes, which expressed CD8 (more than 80% of the cells) and granzyme B (60%-70% of the cells), but were negative for CD4, CD30, and CD56. There was no associationwith Epstein-Barr virus. A clonal T-cell population was detected in 2 patients. Staging examinations did not reveal extracutaneous involvement. The 2 patients with solitary lesions underwent complete remission after radiation therapy, whereas 1 patient developed multifocal lesions and several recurrences. These CD8+ small-to medium-sized lymphoproliferations of the skin at extrafacial sites may belong to a spectrum of phenotypically and prognostically heterogeneous cutaneous small-to med

Název v anglickém jazyce

Primary Cutaneous CD8+Small-to Medium-Sized Lymphoproliferative Disorder in Extrafacial Sites: Clinicopathologic Features and Concept on Their Classification

Popis výsledku anglicky

Three cases with CD8+ small- to medium-sized lymphoproliferations in the skin at extrafacial sites are described. Clinically, the patients presented with papulonodular or plaque-like lesions without preceding patches. Histopathologically, nonepidermotropic nodular or diffuse infiltrates were composed of small-to medium-sized pleomorphic lymphocytes, which expressed CD8 (more than 80% of the cells) and granzyme B (60%-70% of the cells), but were negative for CD4, CD30, and CD56. There was no associationwith Epstein-Barr virus. A clonal T-cell population was detected in 2 patients. Staging examinations did not reveal extracutaneous involvement. The 2 patients with solitary lesions underwent complete remission after radiation therapy, whereas 1 patient developed multifocal lesions and several recurrences. These CD8+ small-to medium-sized lymphoproliferations of the skin at extrafacial sites may belong to a spectrum of phenotypically and prognostically heterogeneous cutaneous small-to med

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Dermatopathology

ISSN

0193-1091

e-ISSN

—

Svazek periodika

35

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

159-166

Kód UT WoS článku

000316941200007

EID výsledku v databázi Scopus

—