Chemokines in tumor proximal fluids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10337931" target="_blank" >RIV/00216208:11140/17:10337931 - isvavai.cz</a>

Výsledek na webu

<a href="http://biomed.papers.upol.cz/pdfs/bio/2017/01/05.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2017/01/05.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2016.062" target="_blank" >10.5507/bp.2016.062</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chemokines in tumor proximal fluids

Popis výsledku v původním jazyce

Chemokines are chemotactic cytokines produced by leukocytes and other types of cells including tumor cells. Tumor cells also express functional chemokine receptors responding to chemokine signals, promoting cell survival, prolirferation and metastasis formation. Significant concentrations of chemokines are found in the tumor adjacent, non-vascular fluids, collectively called tumor proximal fluids. This review summarizes the expression of CC and CXC chemokines in these fluids. Increased chemokine levels are found in high-grade tumor proximal fluids rather than in low-grade tumors and benign conditions. The data confirm peritumoral fluid chemokines as sensitive diagnostic and prognostic markers, as well as offer support for chemokines and their receptors as potential targets for antitumor therapy.

Název v anglickém jazyce

Chemokines in tumor proximal fluids

Popis výsledku anglicky

Chemokines are chemotactic cytokines produced by leukocytes and other types of cells including tumor cells. Tumor cells also express functional chemokine receptors responding to chemokine signals, promoting cell survival, prolirferation and metastasis formation. Significant concentrations of chemokines are found in the tumor adjacent, non-vascular fluids, collectively called tumor proximal fluids. This review summarizes the expression of CC and CXC chemokines in these fluids. Increased chemokine levels are found in high-grade tumor proximal fluids rather than in low-grade tumors and benign conditions. The data confirm peritumoral fluid chemokines as sensitive diagnostic and prognostic markers, as well as offer support for chemokines and their receptors as potential targets for antitumor therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

161

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

41-49

Kód UT WoS článku

000398093500006

EID výsledku v databázi Scopus

2-s2.0-85016237722