Protein metabolism in guanethidine-treated rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F04%3A00002022" target="_blank" >RIV/00216208:11150/04:00002022 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Protein metabolism in guanethidine-treated rats
Popis výsledku v původním jazyce
The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues.
Název v anglickém jazyce
Protein metabolism in guanethidine-treated rats
Popis výsledku anglicky
The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA303%2F03%2F1512" target="_blank" >GA303/03/1512: Možnosti ovlivnění proteinové bilance u proteokatabolických stavů - vliv inhibitorů proteasomů</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2004
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Experimental Pathology
ISSN
0959-9673
e-ISSN
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Svazek periodika
85
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
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Kód UT WoS článku
000223997200003
EID výsledku v databázi Scopus
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