Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271880" target="_blank" >RIV/00216208:11150/14:10271880 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/14:00428971

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_271.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_271.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Popis výsledku v původním jazyce

Fatty liver disease associated with obesity is an important medical problem and the mechanisms for lipid accumulation in hepatocytes are not fully elucidated yet. Recent findings indicate that mitochondria play an important role in this process. Our dataon hepatocytes in which mitochondria are in contact with other cytosolic structures important for their function, extend observations obtained on isolated mitochondria and confirm inhibition of Complex I activity in hepatocytes isolated from rats fed byhigh fat diet (HFD) compared with controls fed by standard diet (STD). Furthermore we have found that HFD hepatocytes are more sensitive to the peroxidative stress because under these conditions also Complex II activity is disturbed. Therefore in HFD animals decrease of Complex I activity cannot be compensated by Complex II substrates as in STD hepatocytes. Our data indicate that combination of HFD and peroxidative stress potentiates HFD damaging effect of mitochondria because both bran

Název v anglickém jazyce

Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Popis výsledku anglicky

Fatty liver disease associated with obesity is an important medical problem and the mechanisms for lipid accumulation in hepatocytes are not fully elucidated yet. Recent findings indicate that mitochondria play an important role in this process. Our dataon hepatocytes in which mitochondria are in contact with other cytosolic structures important for their function, extend observations obtained on isolated mitochondria and confirm inhibition of Complex I activity in hepatocytes isolated from rats fed byhigh fat diet (HFD) compared with controls fed by standard diet (STD). Furthermore we have found that HFD hepatocytes are more sensitive to the peroxidative stress because under these conditions also Complex II activity is disturbed. Therefore in HFD animals decrease of Complex I activity cannot be compensated by Complex II substrates as in STD hepatocytes. Our data indicate that combination of HFD and peroxidative stress potentiates HFD damaging effect of mitochondria because both bran

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/LL1204" target="_blank" >LL1204: Genetická analýza mitochondriálního proteomu: Integrace mitochondriální-jaderné epistáze s patofyziologickými fenotypy u potkana</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

63

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

271-274

Kód UT WoS článku

000336459800016

EID výsledku v databázi Scopus

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