Attenuation of radiation - induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10316910" target="_blank" >RIV/00216208:11150/15:10316910 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/15:43875485 RIV/00179906:_____/15:10316910

Výsledek na webu

<a href="http://www.tandfonline.com/doi/full/10.3109/09553002.2015.1054528" target="_blank" >http://www.tandfonline.com/doi/full/10.3109/09553002.2015.1054528</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/09553002.2015.1054528" target="_blank" >10.3109/09553002.2015.1054528</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Attenuation of radiation - induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice

Popis výsledku v původním jazyce

Purpose: We examined the effect of epidermal growth factor (EGF) and bone marrow transplantation (BMT) on gastrointestinal damage after high-dose irradiation of mice. Material and methods: C57Black/6 mice were used. Two survival experiments were performed (12 and 13 Gy; 60Co, 0.59-0.57 Gy/min). To evaluate BMT and EGF action, five groups were established - 0 Gy, 13 Gy, 13 Gy + EGF (at 2 mg/kg, first dose 24 h after irradiation and then every 48 h), 13 Gy + BMT (5 x 106 cells from green fluorescent protein [GFP] syngenic mice, 4 h after irradiation), and 13 Gy + BMT + EGF. Survival data, blood cell counts, gastrointestine and liver parameters and GFP positive cell migration were measured. Results: BMT and EGF (three doses, at 2 mg/kg, administered 1, 3and 5 days after irradiation) significantly increased survival (13 Gy). In blood, progressive cytopenia was observed with BMT, EGF or their combination having no improving effect early after irradiation. In gastrointestinal system, BMT, E

Název v anglickém jazyce

Attenuation of radiation - induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice

Popis výsledku anglicky

Purpose: We examined the effect of epidermal growth factor (EGF) and bone marrow transplantation (BMT) on gastrointestinal damage after high-dose irradiation of mice. Material and methods: C57Black/6 mice were used. Two survival experiments were performed (12 and 13 Gy; 60Co, 0.59-0.57 Gy/min). To evaluate BMT and EGF action, five groups were established - 0 Gy, 13 Gy, 13 Gy + EGF (at 2 mg/kg, first dose 24 h after irradiation and then every 48 h), 13 Gy + BMT (5 x 106 cells from green fluorescent protein [GFP] syngenic mice, 4 h after irradiation), and 13 Gy + BMT + EGF. Survival data, blood cell counts, gastrointestine and liver parameters and GFP positive cell migration were measured. Results: BMT and EGF (three doses, at 2 mg/kg, administered 1, 3and 5 days after irradiation) significantly increased survival (13 Gy). In blood, progressive cytopenia was observed with BMT, EGF or their combination having no improving effect early after irradiation. In gastrointestinal system, BMT, E

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Radiation Biology

ISSN

0955-3002

e-ISSN

—

Svazek periodika

91

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

703-714

Kód UT WoS článku

000373280900003

EID výsledku v databázi Scopus

2-s2.0-84944750333