Epidermal growth factor attenuates delayed ionizing radiation- induced tissue damage in bone marrow transplanted mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F16%3A43875634" target="_blank" >RIV/60162694:G44__/16:43875634 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/16:10327181 RIV/00179906:_____/16:10327181

Výsledek na webu

<a href="http://www.rrjournal.org/doi/10.1667/RR14247.1" target="_blank" >http://www.rrjournal.org/doi/10.1667/RR14247.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1667/RR14247.1" target="_blank" >10.1667/RR14247.1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Epidermal growth factor attenuates delayed ionizing radiation- induced tissue damage in bone marrow transplanted mice

Popis výsledku v původním jazyce

We examined the effect of epidermal growth factor (EGF) treatment in mice that received bone marrow transplantation (BMT) after 11 Gy whole-body irradiation. C57Bl/6 mice were divided into three treatment groups: 0 Gy; 11 Gy (Co-60, single dose, 0.51 Gy/min) with BMT (5 X 3 10(6) bone marrow cells isolated from green fluorescent protein syngeneic mice, 3-4 h postirradiation); and 11 Gy with BMT and EGF (2 mg/kg applied subcutaneously 1, 3 and 5 days postirradiation). Survival data were collected. Bone marrow, peripheral blood count and cytokines, gastrointestine and liver parameters and migration of green fluorescent protein-positive cells were evaluated at 63 days postirradiation. Epidermal growth factor increased survival of irradiated animals that received BMT from 10.7 to 85.7% at 180 days postirradiation. In the BMT group, we found changes in differential bone marrow and blood count, plasma cytokine levels, gastrointestinal tissues and liver at 63 days postirradiation. These alterations were completely or in some parameters at least partially restored by epidermal growth factor. These findings indicate that epidermal growth factor, administered 1, 3 and 5 days postirradiation in combination with bone marrow transplantation, significantly improves long-term prognosis. (c) 2016 by Radiation Research Society

Název v anglickém jazyce

Epidermal growth factor attenuates delayed ionizing radiation- induced tissue damage in bone marrow transplanted mice

Popis výsledku anglicky

We examined the effect of epidermal growth factor (EGF) treatment in mice that received bone marrow transplantation (BMT) after 11 Gy whole-body irradiation. C57Bl/6 mice were divided into three treatment groups: 0 Gy; 11 Gy (Co-60, single dose, 0.51 Gy/min) with BMT (5 X 3 10(6) bone marrow cells isolated from green fluorescent protein syngeneic mice, 3-4 h postirradiation); and 11 Gy with BMT and EGF (2 mg/kg applied subcutaneously 1, 3 and 5 days postirradiation). Survival data were collected. Bone marrow, peripheral blood count and cytokines, gastrointestine and liver parameters and migration of green fluorescent protein-positive cells were evaluated at 63 days postirradiation. Epidermal growth factor increased survival of irradiated animals that received BMT from 10.7 to 85.7% at 180 days postirradiation. In the BMT group, we found changes in differential bone marrow and blood count, plasma cytokine levels, gastrointestinal tissues and liver at 63 days postirradiation. These alterations were completely or in some parameters at least partially restored by epidermal growth factor. These findings indicate that epidermal growth factor, administered 1, 3 and 5 days postirradiation in combination with bone marrow transplantation, significantly improves long-term prognosis. (c) 2016 by Radiation Research Society

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Research

ISSN

0033-7587

e-ISSN

—

Svazek periodika

186

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

264-274

Kód UT WoS článku

000384352000005

EID výsledku v databázi Scopus

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