The role of endoglin in atherosclerosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124865" target="_blank" >RIV/00216208:11160/12:10124865 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S002191501200158X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S002191501200158X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.atherosclerosis.2012.03.001" target="_blank" >10.1016/j.atherosclerosis.2012.03.001</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The role of endoglin in atherosclerosis
Popis výsledku v původním jazyce
Endoglin (CD 105, TGF-beta receptor III) is a homodimeric transmembrane glycoprotein that plays a regulatory role in TGF-beta signaling. Its functional role in the context of atherosclerosis has yet to be defined and should be stated here. Therefore, wefocused on the role of endoglin in atherosclerosis in both humans and experimental animals. Endoglin expression was demonstrated in atherosclerotic vessels predominantly in endothelial cells and smooth muscle cells in various types of blood vessels in mice and humans, suggesting its participation in atherogenesis. Endoglin expression was also related to the expression of eNOS in endothelium, repair of the vessel wall, plaque neoangiogenesis, production of collagen and stabilization of atherosclerotic lesions. In addition, increased levels of soluble endoglin were associated with hypercholesterolemia, atherosclerosis, acute myocardial infarction and were related to inhibition of TGF-beta signaling in the vessel wall. Moreover, soluble en
Název v anglickém jazyce
The role of endoglin in atherosclerosis
Popis výsledku anglicky
Endoglin (CD 105, TGF-beta receptor III) is a homodimeric transmembrane glycoprotein that plays a regulatory role in TGF-beta signaling. Its functional role in the context of atherosclerosis has yet to be defined and should be stated here. Therefore, wefocused on the role of endoglin in atherosclerosis in both humans and experimental animals. Endoglin expression was demonstrated in atherosclerotic vessels predominantly in endothelial cells and smooth muscle cells in various types of blood vessels in mice and humans, suggesting its participation in atherogenesis. Endoglin expression was also related to the expression of eNOS in endothelium, repair of the vessel wall, plaque neoangiogenesis, production of collagen and stabilization of atherosclerotic lesions. In addition, increased levels of soluble endoglin were associated with hypercholesterolemia, atherosclerosis, acute myocardial infarction and were related to inhibition of TGF-beta signaling in the vessel wall. Moreover, soluble en
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Atherosclerosis
ISSN
0021-9150
e-ISSN
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Svazek periodika
224
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
8
Strana od-do
4-11
Kód UT WoS článku
000308078000002
EID výsledku v databázi Scopus
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