The role of TGF-beta and TGF-beta receptors in atherosclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124901" target="_blank" >RIV/00216208:11160/12:10124901 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.intechopen.com/books/atherogenesis/the-role-of-tgf-beta-and-tgf-beta-receptors-in-atherosclerosis" target="_blank" >http://www.intechopen.com/books/atherogenesis/the-role-of-tgf-beta-and-tgf-beta-receptors-in-atherosclerosis</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/26205" target="_blank" >10.5772/26205</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of TGF-beta and TGF-beta receptors in atherosclerosis

Popis výsledku v původním jazyce

The data presented in this chapter show the importance of TGF-beta1 signaling in atherosclerosis in both animals and humans. Despite a few papers showing participation of TGF-beta1 in early atherosclerosis, most of the papers demonstrate atheroprotectiveeffects of TGF-beta1 signaling. Activation of TGF-beta1 signaling pathway results in anti-inflammatory effects, including decreased expression of cell adhesion molecules (with participation of Smad2 and endoglin), inhibition of inflammation in macrophages, T-cells (with participation of Smad3), increased expression of nitric oxide synthase (with participation of endoglin and Smad2), smooth muscle cells production of collagen and plaques stabilization (with participation of endoglin and Smad2/3). Moreover, reduction of cholesterol levels and/or statin treatment significantly enhances atheroprotective effects of TGF-beta1 signaling.

Název v anglickém jazyce

The role of TGF-beta and TGF-beta receptors in atherosclerosis

Popis výsledku anglicky

The data presented in this chapter show the importance of TGF-beta1 signaling in atherosclerosis in both animals and humans. Despite a few papers showing participation of TGF-beta1 in early atherosclerosis, most of the papers demonstrate atheroprotectiveeffects of TGF-beta1 signaling. Activation of TGF-beta1 signaling pathway results in anti-inflammatory effects, including decreased expression of cell adhesion molecules (with participation of Smad2 and endoglin), inhibition of inflammation in macrophages, T-cells (with participation of Smad3), increased expression of nitric oxide synthase (with participation of endoglin and Smad2), smooth muscle cells production of collagen and plaques stabilization (with participation of endoglin and Smad2/3). Moreover, reduction of cholesterol levels and/or statin treatment significantly enhances atheroprotective effects of TGF-beta1 signaling.

Druh

C - Kapitola v odborné knize

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Atherogenesis

ISBN

978-953-307-992-9

Počet stran výsledku

18

Strana od-do

327-344

Počet stran knihy

570

Název nakladatele

InTech

Místo vydání

Rijeka

Kód UT WoS kapitoly

—