Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312501" target="_blank" >RIV/00216208:11160/15:10312501 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/15:33154999
Výsledek na webu
<a href="http://www.degruyter.com/view/j/acph.2015.65.issue-1/acph-2015-0007/acph-2015-0007.xml" target="_blank" >http://www.degruyter.com/view/j/acph.2015.65.issue-1/acph-2015-0007/acph-2015-0007.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/acph-2015-0007" target="_blank" >10.1515/acph-2015-0007</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo
Popis výsledku v původním jazyce
Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses,on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione re
Název v anglickém jazyce
Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo
Popis výsledku anglicky
Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses,on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione re
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centrum interakcí potravních doplňků s léčivy a nutrigenetiky</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Pharmaceutica
ISSN
1330-0075
e-ISSN
—
Svazek periodika
65
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
HR - Chorvatská republika
Počet stran výsledku
9
Strana od-do
65-73
Kód UT WoS článku
000350879000006
EID výsledku v databázi Scopus
2-s2.0-84924869339