Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150843" target="_blank" >RIV/61989592:15110/14:33150843 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11160/14:10281589
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S1756464614002254" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1756464614002254</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jff.2014.06.026" target="_blank" >10.1016/j.jff.2014.06.026</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
Popis výsledku v původním jazyce
Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements.The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment.The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy.
Název v anglickém jazyce
Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
Popis výsledku anglicky
Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements.The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment.The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Functional Foods
ISSN
1756-4646
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
september
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
9
Strana od-do
327-335
Kód UT WoS článku
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EID výsledku v databázi Scopus
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