Pharmaceutical Applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10374384" target="_blank" >RIV/00216208:11160/17:10374384 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/B9780128092071000161" target="_blank" >http://www.sciencedirect.com/science/article/pii/B9780128092071000161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-809207-1.00016-1" target="_blank" >10.1016/B978-0-12-809207-1.00016-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmaceutical Applications

Popis výsledku v původním jazyce

Supercritical fluid chromatography (SFC) has already become an important complementary technique in separation science due to its high speed, efficiency, and versatility in method development. Its use has been adopted also at various stages of the drug development including three main fields: the drug discovery, quality control of drug substances, and drug products and clinical analysis (bioanalysis). For the latter it is of key importance to provide sensitive and selective determination of drugs and their metabolites in biological material. Therefore SFC coupled to sensitive mass spectrometry detection has become a method of choice. However, the extent of use of SFC in different stages of drug development differs quite substantially. While it is already well-established and widely used in enantioseparation and purification tasks, its use in impurity profiling and clinical applications has only become interesting recently and such studies have started to appear more significantly since about 2012.

Název v anglickém jazyce

Pharmaceutical Applications

Popis výsledku anglicky

Supercritical fluid chromatography (SFC) has already become an important complementary technique in separation science due to its high speed, efficiency, and versatility in method development. Its use has been adopted also at various stages of the drug development including three main fields: the drug discovery, quality control of drug substances, and drug products and clinical analysis (bioanalysis). For the latter it is of key importance to provide sensitive and selective determination of drugs and their metabolites in biological material. Therefore SFC coupled to sensitive mass spectrometry detection has become a method of choice. However, the extent of use of SFC in different stages of drug development differs quite substantially. While it is already well-established and widely used in enantioseparation and purification tasks, its use in impurity profiling and clinical applications has only become interesting recently and such studies have started to appear more significantly since about 2012.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Supercritical Fluid Chromatography

ISBN

978-0-12-809207-1

Počet stran výsledku

34

Strana od-do

461-494

Počet stran knihy

558

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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