Mono and dihydroxy coumarin derivatives: Copper chelation and reduction ability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381848" target="_blank" >RIV/00216208:11160/18:10381848 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0946672X17307137" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0946672X17307137</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jtemb.2017.11.014" target="_blank" >10.1016/j.jtemb.2017.11.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mono and dihydroxy coumarin derivatives: Copper chelation and reduction ability

Popis výsledku v původním jazyce

This study tested the interaction of a series of natural coumarins and their synthetic analogs with copper. Both competitive and non-competitive methods have been employed. Non-competitive studies showed that cuprous ions are not chelated at all and that the stoichiometries of the most active 6,7- and 7,8-dihydroxycoumarins to cupric ions ranged from 1:1 to 2:1 depending on pH and concentration. Interestingly, under highly competitive conditions, coumarins were not capable of chelating cupric ions, either. Reduction experiments have shown that 13 out of the 15 coumarins included in this study reduced cupric ions. However, significant differences depending on their structures were apparent in their potencies. O-dihydroxycoumarins were the most potent ones again.

Název v anglickém jazyce

Mono and dihydroxy coumarin derivatives: Copper chelation and reduction ability

Popis výsledku anglicky

This study tested the interaction of a series of natural coumarins and their synthetic analogs with copper. Both competitive and non-competitive methods have been employed. Non-competitive studies showed that cuprous ions are not chelated at all and that the stoichiometries of the most active 6,7- and 7,8-dihydroxycoumarins to cupric ions ranged from 1:1 to 2:1 depending on pH and concentration. Interestingly, under highly competitive conditions, coumarins were not capable of chelating cupric ions, either. Reduction experiments have shown that 13 out of the 15 coumarins included in this study reduced cupric ions. However, significant differences depending on their structures were apparent in their potencies. O-dihydroxycoumarins were the most potent ones again.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Trace Elements in Medicine and Biology

ISSN

0946-672X

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

88-95

Kód UT WoS článku

000427665400012

EID výsledku v databázi Scopus

2-s2.0-85036526617