Recent developments in supercritical fluid chromatography - mass spectrometry: Is it a viable option for analysis of complex samples?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F19%3A10400890" target="_blank" >RIV/00216208:11160/19:10400890 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LbsDo5sucB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LbsDo5sucB</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.trac.2018.12.023" target="_blank" >10.1016/j.trac.2018.12.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Recent developments in supercritical fluid chromatography - mass spectrometry: Is it a viable option for analysis of complex samples?

Popis výsledku v původním jazyce

Supercritical fluid chromatography (SFC) is known since the early 1960&apos;s and it has gone through several ups and downs during the past 50 years. The most remarkable rebirth came at the beginning of the millennium, when SFC gained its popularity in many laboratories due to the significant improvements in instrumentation resulting in high reliability and robustness. New developments in SFC column chemistries and possibility of mixing CO2 with organic solvents allowed the analysis of various compounds differing in polarities, acid-base properties, and molecular weight. Hyphenation of advanced SFC platforms with mass spectrometry (MS) provides benefits similar to liquid chromatography (LC) hyphenated with MS, i.e. sensitivity and selectivity. SFC is complementary to the most widely used reversed phase LC due to the similar polarity profile to normal phase LC. This orthogonality and different separation mechanism can effectively solve the presence of matrix effects or challenging separations. In addition, SFC can be beneficial in analysis of chiral or unstable compounds difficult to analyze in LC or GC. Current SFC-MS is mostly used as a fast and green approach in a variety of research fields including bioanalysis, omics sciences, plant, food, and environmental analyses.

Název v anglickém jazyce

Recent developments in supercritical fluid chromatography - mass spectrometry: Is it a viable option for analysis of complex samples?

Popis výsledku anglicky

Supercritical fluid chromatography (SFC) is known since the early 1960&apos;s and it has gone through several ups and downs during the past 50 years. The most remarkable rebirth came at the beginning of the millennium, when SFC gained its popularity in many laboratories due to the significant improvements in instrumentation resulting in high reliability and robustness. New developments in SFC column chemistries and possibility of mixing CO2 with organic solvents allowed the analysis of various compounds differing in polarities, acid-base properties, and molecular weight. Hyphenation of advanced SFC platforms with mass spectrometry (MS) provides benefits similar to liquid chromatography (LC) hyphenated with MS, i.e. sensitivity and selectivity. SFC is complementary to the most widely used reversed phase LC due to the similar polarity profile to normal phase LC. This orthogonality and different separation mechanism can effectively solve the presence of matrix effects or challenging separations. In addition, SFC can be beneficial in analysis of chiral or unstable compounds difficult to analyze in LC or GC. Current SFC-MS is mostly used as a fast and green approach in a variety of research fields including bioanalysis, omics sciences, plant, food, and environmental analyses.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/EF15_003%2F0000465" target="_blank" >EF15_003/0000465: Vytvoření expertního týmu pro pokročilý výzkum v separačních vědách</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Analytical Chemistry

ISSN

0165-9936

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

212-225

Kód UT WoS článku

000458499300017

EID výsledku v databázi Scopus

2-s2.0-85060306462