Antioxidant and Anti-Pollution Effect of Naturally Occurring Carotenoids Astaxanthin and Crocin for Human Skin Protection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F22%3A10458656" target="_blank" >RIV/00216208:11160/22:10458656 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.riSwoNEmw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.riSwoNEmw</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/slct.202201595" target="_blank" >10.1002/slct.202201595</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antioxidant and Anti-Pollution Effect of Naturally Occurring Carotenoids Astaxanthin and Crocin for Human Skin Protection

Popis výsledku v původním jazyce

Four in vitro oxidative-stress models were used to study the antioxidant/antipollution effects of all-trans-astaxanthin and crocin compared to synthetic antioxidants. DPPH-scavenging activity of astaxanthin (5 mu M) was 2.4, 1.3, 1.4, 1.1 and 0.9-fold higher than that of alpha-tocopherol (AT), butylhydroxytoluene, butylhydroxyanisole, gallic acid and Trolox, respectively. Crocin scavenged the same radicals amount as butylhydroxytoluene and butylhydroxyanisole. Both carotenoids were more effective at reducing ferric ions than synthetic antioxidants and had a protective effect on the viability of stressed epidermal cells. Reactive oxygen species induced by hydrogen peroxide or cigarette smoke on a skin were quenched with astaxanthin and crocin to approximately the same extent as with AT. ASX was 3.8, 2.3 and 14-fold better singlet oxygen scavenger than Trolox, AT and gallic acid, respectively. The polyunsaturated fatty acids in the astaxanthin&apos; emulsion were 6.5 and 2.5-fold more resistant to oxidation than in the control emulsion and the AT&apos; emulsion, respectively.

Název v anglickém jazyce

Antioxidant and Anti-Pollution Effect of Naturally Occurring Carotenoids Astaxanthin and Crocin for Human Skin Protection

Popis výsledku anglicky

Four in vitro oxidative-stress models were used to study the antioxidant/antipollution effects of all-trans-astaxanthin and crocin compared to synthetic antioxidants. DPPH-scavenging activity of astaxanthin (5 mu M) was 2.4, 1.3, 1.4, 1.1 and 0.9-fold higher than that of alpha-tocopherol (AT), butylhydroxytoluene, butylhydroxyanisole, gallic acid and Trolox, respectively. Crocin scavenged the same radicals amount as butylhydroxytoluene and butylhydroxyanisole. Both carotenoids were more effective at reducing ferric ions than synthetic antioxidants and had a protective effect on the viability of stressed epidermal cells. Reactive oxygen species induced by hydrogen peroxide or cigarette smoke on a skin were quenched with astaxanthin and crocin to approximately the same extent as with AT. ASX was 3.8, 2.3 and 14-fold better singlet oxygen scavenger than Trolox, AT and gallic acid, respectively. The polyunsaturated fatty acids in the astaxanthin&apos; emulsion were 6.5 and 2.5-fold more resistant to oxidation than in the control emulsion and the AT&apos; emulsion, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemistrySelect

ISSN

2365-6549

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

28

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

e202201595

Kód UT WoS článku

000829048100001

EID výsledku v databázi Scopus

2-s2.0-85134961966