Characterization of new R-naphthylethyl cyclofructan 6 chiral stationary phase and its comparison with R-naphthylethyl beta-cyclodextrin-based column

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10089765" target="_blank" >RIV/00216208:11310/11:10089765 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.chroma.2011.01.023" target="_blank" >http://dx.doi.org/10.1016/j.chroma.2011.01.023</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chroma.2011.01.023" target="_blank" >10.1016/j.chroma.2011.01.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of new R-naphthylethyl cyclofructan 6 chiral stationary phase and its comparison with R-naphthylethyl beta-cyclodextrin-based column

Popis výsledku v původním jazyce

Derivatized cyclofructans have been recently introduced as a new class of chiral selectors with great application potential. In this study, a R-naphthylethyl-functionalized cyclofructan 6 based chiral stationary phase (RN CF6 CSP) was used for separationof substituted binaphthyl catalysts in the normal phase HPLC mode. Dominant interaction types that play a role in the separation mechanism were revealed by a linear free energy relationship (LFER) method. In order to evaluate the contribution of the substituent on the cyclofructan structure to retention, the R-naphthylethyl-functionalized beta-cyclodextrin (RN CD) CSP was chosen for comparison. Retention factors of 46 widely different solutes. with known solvation parameters, were determined on each ofthe columns under the same mobile phase compositions used for the enantiomeric separations. The LEER results showed that hydrogen bond acidity and polarity/polarizibility have the greatest impact on retention and enantioresolution on the

Název v anglickém jazyce

Characterization of new R-naphthylethyl cyclofructan 6 chiral stationary phase and its comparison with R-naphthylethyl beta-cyclodextrin-based column

Popis výsledku anglicky

Derivatized cyclofructans have been recently introduced as a new class of chiral selectors with great application potential. In this study, a R-naphthylethyl-functionalized cyclofructan 6 based chiral stationary phase (RN CF6 CSP) was used for separationof substituted binaphthyl catalysts in the normal phase HPLC mode. Dominant interaction types that play a role in the separation mechanism were revealed by a linear free energy relationship (LFER) method. In order to evaluate the contribution of the substituent on the cyclofructan structure to retention, the R-naphthylethyl-functionalized beta-cyclodextrin (RN CD) CSP was chosen for comparison. Retention factors of 46 widely different solutes. with known solvation parameters, were determined on each ofthe columns under the same mobile phase compositions used for the enantiomeric separations. The LEER results showed that hydrogen bond acidity and polarity/polarizibility have the greatest impact on retention and enantioresolution on the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chromatography A

ISSN

0021-9673

e-ISSN

—

Svazek periodika

1218

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

1393-1398

Kód UT WoS článku

000288186900010

EID výsledku v databázi Scopus

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