Manganese(II) Complexes as Potential Contrast Agents for MRI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10119151" target="_blank" >RIV/00216208:11310/12:10119151 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/12:33142752

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ejic.201101336" target="_blank" >http://dx.doi.org/10.1002/ejic.201101336</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejic.201101336" target="_blank" >10.1002/ejic.201101336</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Manganese(II) Complexes as Potential Contrast Agents for MRI

Popis výsledku v původním jazyce

Mn2+ has five unpaired d electrons, a long electronic relaxation time, and labile water exchange, which make it an attractive alternative to Gd3+ in the design of contrast agents for medical Magnetic Resonance Imaging. In order to ensure in vivo safety and high contrast agent efficiency, the Mn2+ ion has to be chelated by a ligand that provides high thermodynamic stability and kinetic inertness of the complex and has to have at least one free coordination site for a water molecule. Unfortunately, thesetwo requirements are contradictory, as lower denticity of the ligands, which leads to more inner-sphere water molecules often implies a decreased stability of the complex, and, therefore, it is necessary to find a balance between both requirements. In the last decade, a large amount of experimental data has been collected to characterize the physico-chemical properties of Mn2+ chelates with variable ligand structures. They now allow for establishing trends of how the ligand structure, th

Název v anglickém jazyce

Manganese(II) Complexes as Potential Contrast Agents for MRI

Popis výsledku anglicky

Mn2+ has five unpaired d electrons, a long electronic relaxation time, and labile water exchange, which make it an attractive alternative to Gd3+ in the design of contrast agents for medical Magnetic Resonance Imaging. In order to ensure in vivo safety and high contrast agent efficiency, the Mn2+ ion has to be chelated by a ligand that provides high thermodynamic stability and kinetic inertness of the complex and has to have at least one free coordination site for a water molecule. Unfortunately, thesetwo requirements are contradictory, as lower denticity of the ligands, which leads to more inner-sphere water molecules often implies a decreased stability of the complex, and, therefore, it is necessary to find a balance between both requirements. In the last decade, a large amount of experimental data has been collected to characterize the physico-chemical properties of Mn2+ chelates with variable ligand structures. They now allow for establishing trends of how the ligand structure, th

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Inorganic Chemistry

ISSN

1434-1948

e-ISSN

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Svazek periodika

2012

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1975-1986

Kód UT WoS článku

000302861900009

EID výsledku v databázi Scopus

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