Metallothioneins and zinc in cancer diagnosis and therapy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10126415" target="_blank" >RIV/00216208:11310/12:10126415 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/12:00198099 RIV/00216208:11130/12:8152 RIV/00064203:_____/12:8152 RIV/00216305:26620/12:PU126354
Výsledek na webu
<a href="http://dx.doi.org/10.3109/03602532.2012.725414" target="_blank" >http://dx.doi.org/10.3109/03602532.2012.725414</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03602532.2012.725414" target="_blank" >10.3109/03602532.2012.725414</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Metallothioneins and zinc in cancer diagnosis and therapy
Popis výsledku v původním jazyce
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn(2+) redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in
Název v anglickém jazyce
Metallothioneins and zinc in cancer diagnosis and therapy
Popis výsledku anglicky
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn(2+) redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Drug Metabolism Reviews
ISSN
0360-2532
e-ISSN
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Svazek periodika
44
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
15
Strana od-do
287-301
Kód UT WoS článku
000312218600002
EID výsledku v databázi Scopus
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