Synthesis and biological activity of nitrogen-containing derivatives of ?-santonin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191489" target="_blank" >RIV/00216208:11310/13:10191489 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ksu.kz/files/Vestnik_KSU/Chemistry_4_72_2013.pdf" target="_blank" >http://www.ksu.kz/files/Vestnik_KSU/Chemistry_4_72_2013.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and biological activity of nitrogen-containing derivatives of ?-santonin

Popis výsledku v původním jazyce

The reactions of eudesmanolide ?-santonin with primary and secondary amines were investigated. It was shown that the reactions occured regioselectively at the carbonyl group of ?-lactone ring with formation of the products of aminolysis - hydroxyamides.Furthermore, it was found that the reaction of santonin with semicarbazide and phenylhydrazine flowed through carbonyl group of cross-conjugated cyclodienone to form condensation products and the reaction of santonin with hydroxylamine flowed to give tandem reactions products of Michael-type and condensation. It was revealed that synthetic nitrogen-containing derivatives of ?-santonin had antibacterial and antioxidant activity.

Název v anglickém jazyce

Synthesis and biological activity of nitrogen-containing derivatives of ?-santonin

Popis výsledku anglicky

The reactions of eudesmanolide ?-santonin with primary and secondary amines were investigated. It was shown that the reactions occured regioselectively at the carbonyl group of ?-lactone ring with formation of the products of aminolysis - hydroxyamides.Furthermore, it was found that the reaction of santonin with semicarbazide and phenylhydrazine flowed through carbonyl group of cross-conjugated cyclodienone to form condensation products and the reaction of santonin with hydroxylamine flowed to give tandem reactions products of Michael-type and condensation. It was revealed that synthetic nitrogen-containing derivatives of ?-santonin had antibacterial and antioxidant activity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulletin of Karaganda State University, Series chemistry

ISSN

0142-0843

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

72

Stát vydavatele periodika

KZ - Republika Kazachstán

Počet stran výsledku

3

Strana od-do

37-40

Kód UT WoS článku

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EID výsledku v databázi Scopus

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