Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282662" target="_blank" >RIV/00216208:11310/14:10282662 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/14:00217569 RIV/00216208:11130/14:10282662 RIV/00216224:14310/14:00075726 RIV/00216305:26620/14:PU111498 RIV/00064203:_____/14:10282662
Výsledek na webu
<a href="http://web2.mendelu.cz/af_239_nanotech/data/pub/Electrochemical%20Study%20of%20Ellipticine%20Interaction%20with%20Single%20and%20Double%20Stranded%20Oligonucleotides.pdf" target="_blank" >http://web2.mendelu.cz/af_239_nanotech/data/pub/Electrochemical%20Study%20of%20Ellipticine%20Interaction%20with%20Single%20and%20Double%20Stranded%20Oligonucleotides.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/18715206113139990316" target="_blank" >10.2174/18715206113139990316</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides
Popis výsledku v původním jazyce
Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became avery promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interactiontime and ellipticine concentrations on interactions of ellipticine with single-and double-stranded oligonucleotides was tested too.
Název v anglickém jazyce
Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides
Popis výsledku anglicky
Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became avery promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interactiontime and ellipticine concentrations on interactions of ellipticine with single-and double-stranded oligonucleotides was tested too.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Anti-Cancer Agents in Medicinal Chemistry
ISSN
1871-5206
e-ISSN
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Svazek periodika
14
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
10
Strana od-do
331-340
Kód UT WoS článku
000331462800016
EID výsledku v databázi Scopus
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