Synthesis and biological activity of nitrogen-containing derivatives of estafiatin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10332061" target="_blank" >RIV/00216208:11310/14:10332061 - isvavai.cz</a>

Výsledek na webu

<a href="http://vestnik.ksu.kz/files_vestnik/Chemistry/Chemistry_2_74_2014.pdf" target="_blank" >http://vestnik.ksu.kz/files_vestnik/Chemistry/Chemistry_2_74_2014.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and biological activity of nitrogen-containing derivatives of estafiatin

Popis výsledku v původním jazyce

The reactions of guaianolide of estafiatin with various amines were investigated. It was shown that the aminolysis reactions of γ-lactone ring of estafiatin or reactions of Michael-type conjugate addition or tandem conversions of Michael and Knoevenagel-type were carried out depending on the nature of amines. The regularity of proceeding of estafiatin reactions with secondary aliphatic and aliphatic-aromatic amines was detected. It lies in the fact that the reactions proceed exclusively by Michael reaction and they are completely regioand stereoselective. It was revealed that synthetic nitrogen-containing derivatives of estafiatin had antibacterial and antioxidant activity.

Název v anglickém jazyce

Synthesis and biological activity of nitrogen-containing derivatives of estafiatin

Popis výsledku anglicky

The reactions of guaianolide of estafiatin with various amines were investigated. It was shown that the aminolysis reactions of γ-lactone ring of estafiatin or reactions of Michael-type conjugate addition or tandem conversions of Michael and Knoevenagel-type were carried out depending on the nature of amines. The regularity of proceeding of estafiatin reactions with secondary aliphatic and aliphatic-aromatic amines was detected. It lies in the fact that the reactions proceed exclusively by Michael reaction and they are completely regioand stereoselective. It was revealed that synthetic nitrogen-containing derivatives of estafiatin had antibacterial and antioxidant activity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulletin of Karaganda State University, Series chemistry

ISSN

0142-0843

e-ISSN

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Svazek periodika

neuveden

Číslo periodika v rámci svazku

74

Stát vydavatele periodika

KZ - Republika Kazachstán

Počet stran výsledku

5

Strana od-do

4-8

Kód UT WoS článku

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EID výsledku v databázi Scopus

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