Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315078" target="_blank" >RIV/00216208:11310/15:10315078 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/15:43888758 RIV/61988987:17310/15:A1601EYV

Výsledek na webu

<a href="http://dx.doi.org/10.1128/mBio.01356-15" target="_blank" >http://dx.doi.org/10.1128/mBio.01356-15</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1128/mBio.01356-15" target="_blank" >10.1128/mBio.01356-15</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

Popis výsledku v původním jazyce

Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus, no trypanosomatid parasites naturally infecting Drosophila have been characterized. Here, we establish a new model of trypanosomatid infection in Drosophila-Jaenimonas drosophilae, gen. et sp. nov. As far as we are aware, this is the first Drosophila-parasitic trypanosomatid to be cultured and characterized. Through experimental infections, we find that Drosophila falleni, the natural host, is highly susceptible to infection, leading to a substantial decrease in host fecundity. J. drosophilae has abroad host range, readily infecting a number of Drosophila species, including D. melanogaster, with oral infection of D. melanogaster larvae resulting in the induction of numerous immune genes. When injected into adult hemolymph, J. droso

Název v anglickém jazyce

Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

Popis výsledku anglicky

Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus, no trypanosomatid parasites naturally infecting Drosophila have been characterized. Here, we establish a new model of trypanosomatid infection in Drosophila-Jaenimonas drosophilae, gen. et sp. nov. As far as we are aware, this is the first Drosophila-parasitic trypanosomatid to be cultured and characterized. Through experimental infections, we find that Drosophila falleni, the natural host, is highly susceptible to infection, leading to a substantial decrease in host fecundity. J. drosophilae has abroad host range, readily infecting a number of Drosophila species, including D. melanogaster, with oral infection of D. melanogaster larvae resulting in the induction of numerous immune genes. When injected into adult hemolymph, J. droso

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

mBio [online]

ISSN

2150-7511

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000364523100041

EID výsledku v databázi Scopus

2-s2.0-84946594500