Infection dynamics and immune response in a newly described Drosophila-trypanosomatid association/n
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00453442" target="_blank" >RIV/60077344:_____/15:00453442 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1128/mBio.01356-15" target="_blank" >http://dx.doi.org/10.1128/mBio.01356-15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/mBio.01356-15" target="_blank" >10.1128/mBio.01356-15</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Infection dynamics and immune response in a newly described Drosophila-trypanosomatid association/n
Popis výsledku v původním jazyce
Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus, no trypanosomatid parasites naturally infecting Drosophila have been characterized. Here, we establish a new model of trypanosomatid infection in Drosophila-Jaenimonas drosophilae, gen. et sp. nov. As far as we are aware, this is the first Drosophila-parasitic trypanosomatid to be cultured and characterized. Through experimental infections, we find that Drosophila falleni, the natural host, is highly susceptible to infection, leading to a substantial decrease in host fecundity. J. drosophilae has abroad host range, readily infecting a number of Drosophila species, including D. melanogaster, with oral infection of D. melanogaster larvae resulting in the induction of numerous immune genes. When injected into adult hemolymph, J. droso
Název v anglickém jazyce
Infection dynamics and immune response in a newly described Drosophila-trypanosomatid association/n
Popis výsledku anglicky
Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus, no trypanosomatid parasites naturally infecting Drosophila have been characterized. Here, we establish a new model of trypanosomatid infection in Drosophila-Jaenimonas drosophilae, gen. et sp. nov. As far as we are aware, this is the first Drosophila-parasitic trypanosomatid to be cultured and characterized. Through experimental infections, we find that Drosophila falleni, the natural host, is highly susceptible to infection, leading to a substantial decrease in host fecundity. J. drosophilae has abroad host range, readily infecting a number of Drosophila species, including D. melanogaster, with oral infection of D. melanogaster larvae resulting in the induction of numerous immune genes. When injected into adult hemolymph, J. droso
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GA14-23986S" target="_blank" >GA14-23986S: Vznik patogenity pro obratlovce: vhled diky puvodnim bodonidum a hmyzim trypanosomatidum</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
mBio
ISSN
2150-7511
e-ISSN
—
Svazek periodika
6
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
—
Kód UT WoS článku
000364523100041
EID výsledku v databázi Scopus
—