Ln(III)-complexes of a DOTA analogue with an ethylenediamine pendant arm as pH-responsive PARACEST contrast agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10323200" target="_blank" >RIV/00216208:11310/16:10323200 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10323200 RIV/00023001:_____/16:00059826

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c5dt04443j" target="_blank" >http://dx.doi.org/10.1039/c5dt04443j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c5dt04443j" target="_blank" >10.1039/c5dt04443j</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ln(III)-complexes of a DOTA analogue with an ethylenediamine pendant arm as pH-responsive PARACEST contrast agents

Popis výsledku v původním jazyce

A novel macrocyclic DO3A derivative containing a linear diamine pendant arm, H(3)do3aNN, was prepared and its protonation and complexation properties were studied by means of potentiometry. It determined ligand consecutive protonation constants log K-An = 12.62, 10.28, 9.67, 8.30, 3.30 and 1.58 and stability constants of selected lanthanide (Eu(III), Yb(III)) complexes log K-EuL = 23.16 and log K-YbL = 22.76. The complexes could be protonated on the pendant amino group(s) with log K(HLM) approximate to 5.6 and log K(H2LM) approximate to 4.8. Solution structures of both complexes were studied by NMR spectroscopy. The study revealed that the complex species exist exclusively in the form of twisted-square-antiprismatic (TSA) isomers. The complexes show significant pH dependence of the Chemical Exchange Saturation Transfer (CEST) between their amino groups and the bulk water molecules in the pH range of 5-8. Thus, the pH dependence of the magnetization transfer ratio of CEST signals can be used for pH determination using magnetic resonance imaging techniques in a pH range relevant for in vivo conditions.

Název v anglickém jazyce

Ln(III)-complexes of a DOTA analogue with an ethylenediamine pendant arm as pH-responsive PARACEST contrast agents

Popis výsledku anglicky

A novel macrocyclic DO3A derivative containing a linear diamine pendant arm, H(3)do3aNN, was prepared and its protonation and complexation properties were studied by means of potentiometry. It determined ligand consecutive protonation constants log K-An = 12.62, 10.28, 9.67, 8.30, 3.30 and 1.58 and stability constants of selected lanthanide (Eu(III), Yb(III)) complexes log K-EuL = 23.16 and log K-YbL = 22.76. The complexes could be protonated on the pendant amino group(s) with log K(HLM) approximate to 5.6 and log K(H2LM) approximate to 4.8. Solution structures of both complexes were studied by NMR spectroscopy. The study revealed that the complex species exist exclusively in the form of twisted-square-antiprismatic (TSA) isomers. The complexes show significant pH dependence of the Chemical Exchange Saturation Transfer (CEST) between their amino groups and the bulk water molecules in the pH range of 5-8. Thus, the pH dependence of the magnetization transfer ratio of CEST signals can be used for pH determination using magnetic resonance imaging techniques in a pH range relevant for in vivo conditions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Nové třídy kontrastních látek pro tomografii magnetické rezonance</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dalton Transactions

ISSN

1477-9226

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

3486-3496

Kód UT WoS článku

000371028600034

EID výsledku v databázi Scopus

2-s2.0-84959252414