Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10360820" target="_blank" >RIV/00216208:11310/17:10360820 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s10337-017-3244-z" target="_blank" >https://doi.org/10.1007/s10337-017-3244-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-017-3244-z" target="_blank" >10.1007/s10337-017-3244-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE

Popis výsledku v původním jazyce

A new CE method for separation of (R,S)-aclidinium bromide enantiomers has been developed and validated. In this method, sulphated gamma-CD 4.8% (w/v) in acidic background electrolyte based on potassium dihydrogen phosphate (100 mM, pH = 3.0) buffer was used for the determination in an uncoated fused silica capillary with extended capillary light path. The effect on the resolution of the chiral selector concentration, of the pH of the background electrolyte and also of other parameters was studied. (R)-Aclidinium bromide has therapeutic properties and, thus, a screening method is required for determination of low concentrations of (S)-aclidinium bromide as an optical impurity. The proposed method enables determination of 0.4% (S)-aclidinium bromide as an optical impurity in a synthetic laboratory sample.

Název v anglickém jazyce

Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE

Popis výsledku anglicky

A new CE method for separation of (R,S)-aclidinium bromide enantiomers has been developed and validated. In this method, sulphated gamma-CD 4.8% (w/v) in acidic background electrolyte based on potassium dihydrogen phosphate (100 mM, pH = 3.0) buffer was used for the determination in an uncoated fused silica capillary with extended capillary light path. The effect on the resolution of the chiral selector concentration, of the pH of the background electrolyte and also of other parameters was studied. (R)-Aclidinium bromide has therapeutic properties and, thus, a screening method is required for determination of low concentrations of (S)-aclidinium bromide as an optical impurity. The proposed method enables determination of 0.4% (S)-aclidinium bromide as an optical impurity in a synthetic laboratory sample.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chromatographia

ISSN

0009-5893

e-ISSN

—

Svazek periodika

80

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

559-563

Kód UT WoS článku

000399024500006

EID výsledku v databázi Scopus

2-s2.0-85009865569