Synthesis and radical scavenging activity of cinnamic acid esters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10367839" target="_blank" >RIV/00216208:11310/17:10367839 - isvavai.cz</a>

Výsledek na webu

<a href="http://bcc.bas.bg/BCC_Volumes/Volume_49_Special_E_2017/BCC-49-E-2017-68-73-Chochkova-14.pdf" target="_blank" >http://bcc.bas.bg/BCC_Volumes/Volume_49_Special_E_2017/BCC-49-E-2017-68-73-Chochkova-14.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and radical scavenging activity of cinnamic acid esters

Popis výsledku v původním jazyce

Cinnamic and hydoxycinnamic acid esters (alpha, beta-unsaturated esters), functional derivatives of cinnamic acids (cinnamic, ferulic, sinapic, caffeic) are secondary plant methabolites derived from phenylpropanoid pathway. Cinnamates, of both natural and synthetic origin, continue to elicit great interest due to diversity of biological activities they possess, such as: antioxidant, antimicrobial, anticancer, anti-inflammatory, anti-tyrosinase and etc. Herein, the reduction of N alpha- and side chain protected amino acids to N-protected amino alcohols and the coupling of the latest with hydroxycinnamic (sinapic and ferulic) acids is described. 1,1-Diphenyl-2-picrylhydrazyl (DPPH radical) scavenging activities of hydroxycinnamates were compared with their corresponding N-hydroxycinnamoyl amino acid amides. Free hydroxycinnamic acids were used as positive controls. The results indicated that N-hydroxycinnamoyl amino acid amides exhibited lower scavenging ability than the corresponding free hydroxycinnamic acids, but higher one than hydroxycinnamates.

Název v anglickém jazyce

Synthesis and radical scavenging activity of cinnamic acid esters

Popis výsledku anglicky

Cinnamic and hydoxycinnamic acid esters (alpha, beta-unsaturated esters), functional derivatives of cinnamic acids (cinnamic, ferulic, sinapic, caffeic) are secondary plant methabolites derived from phenylpropanoid pathway. Cinnamates, of both natural and synthetic origin, continue to elicit great interest due to diversity of biological activities they possess, such as: antioxidant, antimicrobial, anticancer, anti-inflammatory, anti-tyrosinase and etc. Herein, the reduction of N alpha- and side chain protected amino acids to N-protected amino alcohols and the coupling of the latest with hydroxycinnamic (sinapic and ferulic) acids is described. 1,1-Diphenyl-2-picrylhydrazyl (DPPH radical) scavenging activities of hydroxycinnamates were compared with their corresponding N-hydroxycinnamoyl amino acid amides. Free hydroxycinnamic acids were used as positive controls. The results indicated that N-hydroxycinnamoyl amino acid amides exhibited lower scavenging ability than the corresponding free hydroxycinnamic acids, but higher one than hydroxycinnamates.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulgarian Chemical Communications

ISSN

0324-1130

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

Special Issue E

Stát vydavatele periodika

BG - Bulharská republika

Počet stran výsledku

6

Strana od-do

68-73

Kód UT WoS článku

000418303600015

EID výsledku v databázi Scopus

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