Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10374394" target="_blank" >RIV/00216208:11310/18:10374394 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.poly.2017.11.052" target="_blank" >https://doi.org/10.1016/j.poly.2017.11.052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2017.11.052" target="_blank" >10.1016/j.poly.2017.11.052</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
Popis výsledku v původním jazyce
Four novel Zn(II) complexes containing fenamic acid (Hfen), a precursor of non-steroidal anti-inflammatory drugs (NSAIDs), and different coligands namely methanol, N,N,N',N'-tetramethylethylene diamine (tmen), N,N'-bis(3-aminopropyl)ethylenediamine (bapen) and 14,811-tetraazacyclotetradecane (cyclam) were prepared in crystalline form. The composition of the complexes was determined by infrared spectroscopy, elemental and thermal analyses. Results of single-crystal X-ray structure analysis have revealed that while complex 1 is composed of trinuclear [Zn-3(fen)(6)(MeOH)(2)] molecules, the three remaining complexes 2-4 are mononuclear with composition [Zn(fen)(2)(tmen)] (2), [Zn(bapen)(fen)]fen (3), and [Zn (cyclam)(fen)(2)] (4). Binding of all prepared complexes to calf thymus DNA was investigated using UV-vis, fluorescence and circular dichroism (CD) measurements. In addition, inhibition activity of complexes against topoisomerase I along with antimicrobial activity was determined.
Název v anglickém jazyce
Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
Popis výsledku anglicky
Four novel Zn(II) complexes containing fenamic acid (Hfen), a precursor of non-steroidal anti-inflammatory drugs (NSAIDs), and different coligands namely methanol, N,N,N',N'-tetramethylethylene diamine (tmen), N,N'-bis(3-aminopropyl)ethylenediamine (bapen) and 14,811-tetraazacyclotetradecane (cyclam) were prepared in crystalline form. The composition of the complexes was determined by infrared spectroscopy, elemental and thermal analyses. Results of single-crystal X-ray structure analysis have revealed that while complex 1 is composed of trinuclear [Zn-3(fen)(6)(MeOH)(2)] molecules, the three remaining complexes 2-4 are mononuclear with composition [Zn(fen)(2)(tmen)] (2), [Zn(bapen)(fen)]fen (3), and [Zn (cyclam)(fen)(2)] (4). Binding of all prepared complexes to calf thymus DNA was investigated using UV-vis, fluorescence and circular dichroism (CD) measurements. In addition, inhibition activity of complexes against topoisomerase I along with antimicrobial activity was determined.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Polyhedron
ISSN
0277-5387
e-ISSN
—
Svazek periodika
141
Číslo periodika v rámci svazku
February
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
230-238
Kód UT WoS článku
000424961200030
EID výsledku v databázi Scopus
2-s2.0-85038004060