Enantioselective Synthesis of Spiro Heterocycles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10458296" target="_blank" >RIV/00216208:11310/22:10458296 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/9781119567646.ch7" target="_blank" >https://doi.org/10.1002/9781119567646.ch7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781119567646.ch7" target="_blank" >10.1002/9781119567646.ch7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enantioselective Synthesis of Spiro Heterocycles

Popis výsledku v původním jazyce

This chapter reviews catalytic synthetic methods allowing enantioselective construction of spiro heterocyclic compounds, excluding oxindole motif. It discusses the enantioselective methods for the construction of spirocycles with one heteroatom, such as nitrogen-containing heterocycles (pyrrolidine, indolizine, and piperidine), oxygen- and sulfur-containing heterocycles (furanone, benzofuranone, and pyrane). N-Heterocyclic carbene catalysis can be used for the enantioselective synthesis of spiroindolenines. Among catalytic approaches, asymmetric organocatalysis predominates in the preparation of chiral sulfur-containing spiro compounds. The organic chemists have studied catalytic approaches to synthesize chiral spirocyclic compounds containing more than one spiro atom; some of them led to structurally valuable substances. The chapter presents synthetic strategies for the preparation of chiral spirocycles containing more than one heteroatom, including pyrazolones, azlactones, barbituric acid derivatives, sultams. It also presents catalytic methods for enantioselective preparation of other types of spiro heterocycles and bispiro compounds.

Název v anglickém jazyce

Enantioselective Synthesis of Spiro Heterocycles

Popis výsledku anglicky

This chapter reviews catalytic synthetic methods allowing enantioselective construction of spiro heterocyclic compounds, excluding oxindole motif. It discusses the enantioselective methods for the construction of spirocycles with one heteroatom, such as nitrogen-containing heterocycles (pyrrolidine, indolizine, and piperidine), oxygen- and sulfur-containing heterocycles (furanone, benzofuranone, and pyrane). N-Heterocyclic carbene catalysis can be used for the enantioselective synthesis of spiroindolenines. Among catalytic approaches, asymmetric organocatalysis predominates in the preparation of chiral sulfur-containing spiro compounds. The organic chemists have studied catalytic approaches to synthesize chiral spirocyclic compounds containing more than one spiro atom; some of them led to structurally valuable substances. The chapter presents synthetic strategies for the preparation of chiral spirocycles containing more than one heteroatom, including pyrazolones, azlactones, barbituric acid derivatives, sultams. It also presents catalytic methods for enantioselective preparation of other types of spiro heterocycles and bispiro compounds.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/GA20-29336S" target="_blank" >GA20-29336S: Enantioselektivní transformace katalyzované Brønstedovými kyselinami a chirálními aminy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Spiro Compounds: Synthesis and Applications

ISBN

978-1-119-56763-9

Počet stran výsledku

78

Strana od-do

205-282

Počet stran knihy

444

Název nakladatele

John Wiley &amp; Sons, Inc.

Místo vydání

Hoboken, NJ

Kód UT WoS kapitoly

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