Efficient RNA pairwise structure comparison by SETTER method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F12%3A10124054" target="_blank" >RIV/00216208:11320/12:10124054 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/12:43893493

Výsledek na webu

<a href="http://dx.doi.org/10.1093/bioinformatics/bts301" target="_blank" >http://dx.doi.org/10.1093/bioinformatics/bts301</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/bioinformatics/bts301" target="_blank" >10.1093/bioinformatics/bts301</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Efficient RNA pairwise structure comparison by SETTER method

Popis výsledku v původním jazyce

Motivation: Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their 3D structures. Although a structural alignment of short RNAs is achievable in a reasonable amount of time, large structures represent much bigger challenge. However, the growth of the number of large RNAs deposited in the PDB database calls for the development of fast and accurate methods for analyzing their structures, as well as for rapid similarity searches in databases. Results: In this article a novel algorithm for an RNA structural comparison SETTER (SEcondary sTructure-based TERtiary Structure Similarity Algorithm) is introduced. SETTER uses a pairwise comparison method based on 3D similarity of the so-called generalized secondary structure units. For each pair of structures, SETTER produces a distance score and an indication of its statistical significance. SETTER can be used both for the structural alignments of structures that are already known to be hom

Název v anglickém jazyce

Efficient RNA pairwise structure comparison by SETTER method

Popis výsledku anglicky

Motivation: Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their 3D structures. Although a structural alignment of short RNAs is achievable in a reasonable amount of time, large structures represent much bigger challenge. However, the growth of the number of large RNAs deposited in the PDB database calls for the development of fast and accurate methods for analyzing their structures, as well as for rapid similarity searches in databases. Results: In this article a novel algorithm for an RNA structural comparison SETTER (SEcondary sTructure-based TERtiary Structure Similarity Algorithm) is introduced. SETTER uses a pairwise comparison method based on 3D similarity of the so-called generalized secondary structure units. For each pair of structures, SETTER produces a distance score and an indication of its statistical significance. SETTER can be used both for the structural alignments of structures that are already known to be hom

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

<a href="/cs/project/GAP202%2F11%2F0968" target="_blank" >GAP202/11/0968: Podobnostní nemetrické vyhledávání v rozsáhlých komplexních databázích</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOINFORMATICS

ISSN

1367-4803

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1858-1864

Kód UT WoS článku

000306136100009

EID výsledku v databázi Scopus

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