MultiSETTER: web server for multiple RNA structure comparison

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900544" target="_blank" >RIV/60461373:22310/15:43900544 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11320/15:10323525

Výsledek na webu

<a href="http://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0696-8" target="_blank" >http://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0696-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12859-015-0696-8" target="_blank" >10.1186/s12859-015-0696-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MultiSETTER: web server for multiple RNA structure comparison

Popis výsledku v původním jazyce

Background: Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm.Results: In this paper, we present the updated version of the SETTER web server that implements a user friendly interface to the MultiSETTER algorithm. The server accepts RNA structures either as the list of PDB IDs or as user-defined PDB

Název v anglickém jazyce

MultiSETTER: web server for multiple RNA structure comparison

Popis výsledku anglicky

Background: Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm.Results: In this paper, we present the updated version of the SETTER web server that implements a user friendly interface to the MultiSETTER algorithm. The server accepts RNA structures either as the list of PDB IDs or as user-defined PDB

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Bioinformatics

ISSN

1471-2105

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

253

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000359281500003

EID výsledku v databázi Scopus

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