Post-infection immunity provides excellent protection from COVID-19 ICU hospitalization during Delta and Omicron waves

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F23%3A10452130" target="_blank" >RIV/00216208:11320/23:10452130 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/22:A2302GYW

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sPkfvjOlME" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sPkfvjOlME</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/23744235.2022.2125575" target="_blank" >10.1080/23744235.2022.2125575</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Post-infection immunity provides excellent protection from COVID-19 ICU hospitalization during Delta and Omicron waves

Popis výsledku v původním jazyce

We used the official open data covering all COVID-19 cases in the Czech Republic (population of 10.7 mil.) between September 2021 and August 2022 classified according to the vaccination and post-infection statuses to demonstrate the protective effects of vaccination and previous infection on three COVID-19 related outcomes of different severity - PCR positivity, hospitalisations and ICU hospitalisations of COVID-positive patients. The fact that previously uninfected and unvaccinated individuals are much more prone to becoming infected, hospitalised, or admitted to ICU is not surprising; however, the rapid drop in incidences of hospitalised and ICU patients in previously infected cohorts (both vaccinated and unvaccinated) is striking. While during the Delta variant predominance, the immunity conferred by previous infection protected relatively well even from becoming infected (but see below), this protective effect grew much smaller once the Omicron variant took hold. However, the protection from hospitalisations and, particularly, ICU admissions remained very high in the previously infected cohorts, regardless of the vaccination status. This is, in our opinion, a crucial piece of information that remains largely neglected, although its potential implications on the vaccination policies for previously infected individuals are great. We do not discuss or dispute the usefulness of vaccination of previously uninfected individuals here - the fact that to get into the &apos;previously infected&apos; group, one must first survive the original infection must be taken into account. However, considering all the above, we propose that (i) vaccination strategies for previously infected and previously uninfected individuals should differ as previous infection alone provides strong protection from the severe course of the disease and that (ii) previous infection should be taken into account in the risk-benefit analysis and decision making about vaccination on an individual basis.

Název v anglickém jazyce

Post-infection immunity provides excellent protection from COVID-19 ICU hospitalization during Delta and Omicron waves

Popis výsledku anglicky

We used the official open data covering all COVID-19 cases in the Czech Republic (population of 10.7 mil.) between September 2021 and August 2022 classified according to the vaccination and post-infection statuses to demonstrate the protective effects of vaccination and previous infection on three COVID-19 related outcomes of different severity - PCR positivity, hospitalisations and ICU hospitalisations of COVID-positive patients. The fact that previously uninfected and unvaccinated individuals are much more prone to becoming infected, hospitalised, or admitted to ICU is not surprising; however, the rapid drop in incidences of hospitalised and ICU patients in previously infected cohorts (both vaccinated and unvaccinated) is striking. While during the Delta variant predominance, the immunity conferred by previous infection protected relatively well even from becoming infected (but see below), this protective effect grew much smaller once the Omicron variant took hold. However, the protection from hospitalisations and, particularly, ICU admissions remained very high in the previously infected cohorts, regardless of the vaccination status. This is, in our opinion, a crucial piece of information that remains largely neglected, although its potential implications on the vaccination policies for previously infected individuals are great. We do not discuss or dispute the usefulness of vaccination of previously uninfected individuals here - the fact that to get into the &apos;previously infected&apos; group, one must first survive the original infection must be taken into account. However, considering all the above, we propose that (i) vaccination strategies for previously infected and previously uninfected individuals should differ as previous infection alone provides strong protection from the severe course of the disease and that (ii) previous infection should be taken into account in the risk-benefit analysis and decision making about vaccination on an individual basis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10607 - Virology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infectious Diseases

ISSN

2374-4235

e-ISSN

2374-4243

Svazek periodika

55

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

74-77

Kód UT WoS článku

000857358900001

EID výsledku v databázi Scopus

2-s2.0-85138359623