Genomics of Treponema.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00013213" target="_blank" >RIV/00216224:14110/05:00013213 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Genomics of Treponema.

Popis výsledku v původním jazyce

The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbittreponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It islikely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprintin

Název v anglickém jazyce

Genomics of Treponema.

Popis výsledku anglicky

The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbittreponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It islikely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprintin

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů