Vliv polyfenolického extraktu z matolin odrůd André a Modrý Portugal na aktivitu jaterního isoenzymu CYP1A2

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00020487" target="_blank" >RIV/00216224:14110/07:00020487 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE INFLUENCE OF POLYPHENOLIC EXTRACT FROM ANDRE AND BLAUER PORTUGAISER GRAPE BYPRODUCTS ON THE ACTIVITY OF LIVER CYP1A2 ISOENZYME

Popis výsledku v původním jazyce

The enzymatic system of cytochrome P 450 (CYP450) is one of the most important enzymatic systems participating in drug metabolism. Both, the induction and inhibition of specific CYP450 isoenzymes are important in terms of the efficacy or toxicity of drugs that are substrates for this system. Within the genetic polymorphism as an essential definition of activity of CYP450 many other factors influence liver oxidative metabolism (i.e. age, sex, administered drugs, diseases). Nutrition state, components ofdiet and exposure to chemical elements belongs to the most important exogenous ones. Polyphenolic compounds are biologically active substances with many protective effects. As well as other components of diet polyphenols can also influence the activity of liver CYP450 and can interfere with administered drugs metabolized by hepatic isoenzymes of CYP450. The aim of our present study was to investigate the influence of polyphenolic extract from grape byproducts and hypercholesterolemic die

Název v anglickém jazyce

THE INFLUENCE OF POLYPHENOLIC EXTRACT FROM ANDRE AND BLAUER PORTUGAISER GRAPE BYPRODUCTS ON THE ACTIVITY OF LIVER CYP1A2 ISOENZYME

Popis výsledku anglicky

The enzymatic system of cytochrome P 450 (CYP450) is one of the most important enzymatic systems participating in drug metabolism. Both, the induction and inhibition of specific CYP450 isoenzymes are important in terms of the efficacy or toxicity of drugs that are substrates for this system. Within the genetic polymorphism as an essential definition of activity of CYP450 many other factors influence liver oxidative metabolism (i.e. age, sex, administered drugs, diseases). Nutrition state, components ofdiet and exposure to chemical elements belongs to the most important exogenous ones. Polyphenolic compounds are biologically active substances with many protective effects. As well as other components of diet polyphenols can also influence the activity of liver CYP450 and can interfere with administered drugs metabolized by hepatic isoenzymes of CYP450. The aim of our present study was to investigate the influence of polyphenolic extract from grape byproducts and hypercholesterolemic die

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F06%2F1757" target="_blank" >GA525/06/1757: Polyfenolické látky hroznů, révových vín a jejich antimutagenní a antioxidační vlastnosti</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

151

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

109

Strana od-do

104-105

Kód UT WoS článku

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EID výsledku v databázi Scopus

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