Vliv polyfenolických exraktů z vinných matolin na metabolickou aktivitu CYP1A2 u hypercholesterolemických potkanů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00020797" target="_blank" >RIV/00216224:14110/07:00020797 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE INFLUENCE OF POLYPHENOLIC EXTRACTS FROM GRAPE BYPRODUCTS ON THE METABOLIC ACTIVITY OF CYP1A2 IN HYPERCHOLESTEROLAEMIC RATS

Popis výsledku v původním jazyce

The enzymatic system of cytochrome P450 (CYP450)is one of the major metabolic enzyme systems. It takes part in metabolism of many exogenous as well as endogenous substrates and its activity may be influenced by many factors (age, sex, pathophysiologicalstatus). One of these factors which is often missed out is diet. Food contain many substances influencing activity of CYP450 and thus biotransformation of potentially toxic agents including drugs. The aim of our work was to prepare extracts from grape byproducts rich in polyphenols and to investigate their influence on the activity of hepatic CYP1A2 in hypercholesterolaemic rats. Phenacetine (PHEN) and paracetamol (PAR)were used as marker substance and specific metabolite in the model of isolated perfused rat liver. Extracts were a administered to male Wistar albino rats by intragastric sond for 40 days. Rats were suplemented by hypercholesteroleamic diet (1,7%). Hypercholesterolemic diet alone had no effect on the activity of CYP450. I

Název v anglickém jazyce

THE INFLUENCE OF POLYPHENOLIC EXTRACTS FROM GRAPE BYPRODUCTS ON THE METABOLIC ACTIVITY OF CYP1A2 IN HYPERCHOLESTEROLAEMIC RATS

Popis výsledku anglicky

The enzymatic system of cytochrome P450 (CYP450)is one of the major metabolic enzyme systems. It takes part in metabolism of many exogenous as well as endogenous substrates and its activity may be influenced by many factors (age, sex, pathophysiologicalstatus). One of these factors which is often missed out is diet. Food contain many substances influencing activity of CYP450 and thus biotransformation of potentially toxic agents including drugs. The aim of our work was to prepare extracts from grape byproducts rich in polyphenols and to investigate their influence on the activity of hepatic CYP1A2 in hypercholesterolaemic rats. Phenacetine (PHEN) and paracetamol (PAR)were used as marker substance and specific metabolite in the model of isolated perfused rat liver. Extracts were a administered to male Wistar albino rats by intragastric sond for 40 days. Rats were suplemented by hypercholesteroleamic diet (1,7%). Hypercholesterolemic diet alone had no effect on the activity of CYP450. I

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F06%2F1757" target="_blank" >GA525/06/1757: Polyfenolické látky hroznů, révových vín a jejich antimutagenní a antioxidační vlastnosti</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

101

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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