Trans-resveratrol zesiluje mezipohlavní rozdíly v metabolické aktivitě CYP1A2 u potkanů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00024889" target="_blank" >RIV/00216224:14110/08:00024889 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats

Popis výsledku v původním jazyce

Trans-resveratrol (tRES) is a polyphenolic compound present in a variety of plants. TRes elicits many actions in human body which are considered to be protective. Some authors reported tRES influence on the activity of cytochrome P450 (CYP450). It is oneof the major enzymatic systems. Many substances including drugs are metabolized by CYP450. Its activity depends on many factors e.g. genotype, age, sex, or xenobiotics. Changes in CYP450 activity can play an important role in drug effectiveness and toxicity, thus knowledge of xenobiotic influence on this enzyme is important for predicting drug interactions. The aim of our study was to evaluate the influence of sex difference and tRES administration on activity of CYP1A2 in rats. Male and female Wistaralbino rats were used. Animals weighing 200g were housed under controlled conditions with free access to food and water. Animals were divided into 4 groups. Two groups were males and two females. Resveratrol premedicated male (RM) and fem

Název v anglickém jazyce

Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats

Popis výsledku anglicky

Trans-resveratrol (tRES) is a polyphenolic compound present in a variety of plants. TRes elicits many actions in human body which are considered to be protective. Some authors reported tRES influence on the activity of cytochrome P450 (CYP450). It is oneof the major enzymatic systems. Many substances including drugs are metabolized by CYP450. Its activity depends on many factors e.g. genotype, age, sex, or xenobiotics. Changes in CYP450 activity can play an important role in drug effectiveness and toxicity, thus knowledge of xenobiotic influence on this enzyme is important for predicting drug interactions. The aim of our study was to evaluate the influence of sex difference and tRES administration on activity of CYP1A2 in rats. Male and female Wistaralbino rats were used. Animals weighing 200g were housed under controlled conditions with free access to food and water. Animals were divided into 4 groups. Two groups were males and two females. Resveratrol premedicated male (RM) and fem

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F06%2F1757" target="_blank" >GA525/06/1757: Polyfenolické látky hroznů, révových vín a jejich antimutagenní a antioxidační vlastnosti</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

109

Číslo periodika v rámci svazku

S

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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