VPLYV METANANDAMIDU NA AKTIVITU CYTOCHRÓMU P450 AKO PREDIKČNÉHO FAKTORU TOXICITY XENOBIOTÍK V ZÁVISTLOSTI OD POHLAVIA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00023389" target="_blank" >RIV/00216224:14110/07:00023389 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY

Popis výsledku v původním jazyce

The primary active constituent of the hemp plant Cannabis sativa is 9-tetrahydrocannabinol (THC)1. Anandamide, an endogenous ligand for brain cannabinoid CB1 receptor, produces many behavioural effects similar to those of THC. (R)-(+)-methanandamide (MET) is a synthetic long-lasting arachidonylethanolamide (anandamide) analogue. The enzymatic system of cytochrome P450 (CYP450) is part of phase I of enzymatic biotransformation. Interindividual variability of activity of oxidative and conjugating enzymes,especially the system of CYP450, can be based on many exogenous as well as endogenous influences e.g. sex, age or genetic factors. The aim of this work was to investigate the effect of repeated administration of (MET) on rat liver CYP2D2 isoenzyme usingdextromethorphan (DEM) as a specific marker4. We have also studied the role of sex on the activity of CYP2D2 isoenzyme. The activity of CYP2D2 differed due to pretreatment with methanandamide. In our experiments the influence of this com

Název v anglickém jazyce

THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY

Popis výsledku anglicky

The primary active constituent of the hemp plant Cannabis sativa is 9-tetrahydrocannabinol (THC)1. Anandamide, an endogenous ligand for brain cannabinoid CB1 receptor, produces many behavioural effects similar to those of THC. (R)-(+)-methanandamide (MET) is a synthetic long-lasting arachidonylethanolamide (anandamide) analogue. The enzymatic system of cytochrome P450 (CYP450) is part of phase I of enzymatic biotransformation. Interindividual variability of activity of oxidative and conjugating enzymes,especially the system of CYP450, can be based on many exogenous as well as endogenous influences e.g. sex, age or genetic factors. The aim of this work was to investigate the effect of repeated administration of (MET) on rat liver CYP2D2 isoenzyme usingdextromethorphan (DEM) as a specific marker4. We have also studied the role of sex on the activity of CYP2D2 isoenzyme. The activity of CYP2D2 differed due to pretreatment with methanandamide. In our experiments the influence of this com

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

101

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

298-300

Kód UT WoS článku

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EID výsledku v databázi Scopus

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