Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00029916" target="_blank" >RIV/00216224:14110/09:00029916 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.
Popis výsledku v původním jazyce
Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis, T. pallidum ssp. pertenue (TPE) causes endemic treponematosis yaws, and T. paraluiscuniculi is not infectious to humans but causes venereal spirochetosis in rabbits. The genomesof TPE strain Samoa D and T. paraluiscuniculi strain Cuniculi A were sequenced using several whole-genome sequencing methods. Obtained whole genome sequences were compared to the published sequence of TPA strain Nichols. The genome size of TPA Nichols (1,138,006 bp), TPE Samoa D (1,139,299 bp) and T. paraluiscuniculi Cuniculi A (1,133,391 bp) and the overall gene order is similar in all investigated genomes. More than 50% of Nichols and Samoa D genes encode sequentially identical proteins whereas only15% of those genes were found in the Cuniculi A and Samoa D genomes. Major sequence changes including frameshifts were found in 88 genes of the Cuniculi A genome when compared to the Nichols genome.
Název v anglickém jazyce
Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.
Popis výsledku anglicky
Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis, T. pallidum ssp. pertenue (TPE) causes endemic treponematosis yaws, and T. paraluiscuniculi is not infectious to humans but causes venereal spirochetosis in rabbits. The genomesof TPE strain Samoa D and T. paraluiscuniculi strain Cuniculi A were sequenced using several whole-genome sequencing methods. Obtained whole genome sequences were compared to the published sequence of TPA strain Nichols. The genome size of TPA Nichols (1,138,006 bp), TPE Samoa D (1,139,299 bp) and T. paraluiscuniculi Cuniculi A (1,133,391 bp) and the overall gene order is similar in all investigated genomes. More than 50% of Nichols and Samoa D genes encode sequentially identical proteins whereas only15% of those genes were found in the Cuniculi A and Samoa D genomes. Major sequence changes including frameshifts were found in 88 genes of the Cuniculi A genome when compared to the Nichols genome.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2009
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
Clinical Microbiology and Infection, Volume 15, Issue s4, Abstracts of the 19th ECCMID, P1329
ISBN
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ISSN
1198-743X
e-ISSN
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Počet stran výsledku
1
Strana od-do
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Název nakladatele
European Society of Clinical Microbiology and Infectious Diseases
Místo vydání
Neuveden
Místo konání akce
Helsinki
Datum konání akce
16. 5. 2009
Typ akce podle státní příslušnosti
EUR - Evropská akce
Kód UT WoS článku
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