Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00061172" target="_blank" >RIV/00216224:14110/12:00061172 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/12:00390339 RIV/00159816:_____/12:#0000942

Výsledek na webu

<a href="http://dx.doi.org/10.1038/pcan.2012.6" target="_blank" >http://dx.doi.org/10.1038/pcan.2012.6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/pcan.2012.6" target="_blank" >10.1038/pcan.2012.6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Popis výsledku v původním jazyce

Deregulation of expression and function of cytokines belonging to the transforming growth factor-ß (TGF-ß) family is often associated with various pathologies. For example, this cytokine family has been considered a promising target for cancer therapy. However, the detailed functions of several cytokines from the TGF-ß family that could play a role in cancer progression and therapy remain unclear. One of these molecules is growth/differentiation factor-15 (GDF-15), a divergent member of the TGF-ß family. This stress-induced cytokine has been proposed to possess immunomodulatory functions, and its high expression is often associated with cancer progression, including prostate cancer. However, studies clearly demonstrating the mechanisms for signal transduction and functions in cell interaction, cancer progression, and therapy are still lacking. New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for prostate cancer bone metastases.

Název v anglickém jazyce

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Popis výsledku anglicky

Deregulation of expression and function of cytokines belonging to the transforming growth factor-ß (TGF-ß) family is often associated with various pathologies. For example, this cytokine family has been considered a promising target for cancer therapy. However, the detailed functions of several cytokines from the TGF-ß family that could play a role in cancer progression and therapy remain unclear. One of these molecules is growth/differentiation factor-15 (GDF-15), a divergent member of the TGF-ß family. This stress-induced cytokine has been proposed to possess immunomodulatory functions, and its high expression is often associated with cancer progression, including prostate cancer. However, studies clearly demonstrating the mechanisms for signal transduction and functions in cell interaction, cancer progression, and therapy are still lacking. New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for prostate cancer bone metastases.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prostate Cancer And Prostatic Diseases

ISSN

1365-7852

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

320-328

Kód UT WoS článku

000311034200003

EID výsledku v databázi Scopus

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