Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00036202" target="_blank" >RIV/00216224:14310/09:00036202 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts

Popis výsledku v původním jazyce

Prostate cancer is a common disease in industrial countries. Prostate tumors preferentially disseminate to bones and induce significant rearrangement of the bone architecture. T The aim of this study is to characterize effects of growth differentiation factor-15 (GDF-15) secreted by prostate cancer cells on the osteoclastic differentiation pathway. This study documents that GDF-15 both as purified substance and as unpurified product secreted by prostate cancer cells strongly interferes with differentiation of osteoclasts by inhibiting expression and activity of NFkB and c-Fos. This work was supported by grants 301/09/1115 (JS), 204/07/0834 (KS), 310/07/0961 (KS) of the Czech Science Foundation, MSM0021622415 of Ministry of Education, Youth and Sports of the Czech Republic (JS) and AV0Z50040507 of the Grant Agency of Academy of Sciences of the Czech Republic (KS).

Název v anglickém jazyce

Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts

Popis výsledku anglicky

Prostate cancer is a common disease in industrial countries. Prostate tumors preferentially disseminate to bones and induce significant rearrangement of the bone architecture. T The aim of this study is to characterize effects of growth differentiation factor-15 (GDF-15) secreted by prostate cancer cells on the osteoclastic differentiation pathway. This study documents that GDF-15 both as purified substance and as unpurified product secreted by prostate cancer cells strongly interferes with differentiation of osteoclasts by inhibiting expression and activity of NFkB and c-Fos. This work was supported by grants 301/09/1115 (JS), 204/07/0834 (KS), 310/07/0961 (KS) of the Czech Science Foundation, MSM0021622415 of Ministry of Education, Youth and Sports of the Czech Republic (JS) and AV0Z50040507 of the Grant Agency of Academy of Sciences of the Czech Republic (KS).

Druh

D - Stať ve sborníku

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA301%2F09%2F1115" target="_blank" >GA301/09/1115: Úloha proteinů c-Myb a Cox-2 při tvorbě střevních nádorů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

the FEBS Journal, 256, Suppl. 1

ISBN

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ISSN

1742-464X

e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

FEBS

Místo vydání

Prague, Czech Republic

Místo konání akce

Prague, Czech Republic

Datum konání akce

1. 1. 2009

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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