Vliv proteinů rodiny TGFb na diferenciaci osteoklastů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00024950" target="_blank" >RIV/00216224:14310/08:00024950 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

The effects of TGFb proteins on osteoclast differentiation

Popis výsledku v původním jazyce

Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect thebone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of os

Název v anglickém jazyce

The effects of TGFb proteins on osteoclast differentiation

Popis výsledku anglicky

Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect thebone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of os

Druh

D - Stať ve sborníku

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine

ISBN

—

ISSN

1107-3756

e-ISSN

—

Počet stran výsledku

1

Strana od-do

—

Název nakladatele

International Journal of Molecular Medicine Vol. 22, supplement 1, 2008

Místo vydání

Hersonissos, Greece

Místo konání akce

Hersonissos, Greece

Datum konání akce

9. 11. 2008

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—