Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077137" target="_blank" >RIV/00216224:14110/14:00077137 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/14:00061872

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease

Popis výsledku v původním jazyce

Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein" 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n = 51)), andin 155 healthy controls. Biomarkers were measured at diagnosis and compared with disease characteristics. Six significant correlations were found: 1) BALF TFF3 level was associated with HRCT interstitial ?score in IPF (P=0.052); 2) BALF PSP94 level withprognosis of sarcoidosis (P=0.035); 3) BALF SP-A level with pulmonary functions in IPF (P=0.032); 4) BALF SP-D and TT3 with IPF mortality (P=0.049 and 0.017, respectively); 5) serum TT3 level with COPD mortality (P=0.

Název v anglickém jazyce

Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease

Popis výsledku anglicky

Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein" 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n = 51)), andin 155 healthy controls. Biomarkers were measured at diagnosis and compared with disease characteristics. Six significant correlations were found: 1) BALF TFF3 level was associated with HRCT interstitial ?score in IPF (P=0.052); 2) BALF PSP94 level withprognosis of sarcoidosis (P=0.035); 3) BALF SP-A level with pulmonary functions in IPF (P=0.032); 4) BALF SP-D and TT3 with IPF mortality (P=0.049 and 0.017, respectively); 5) serum TT3 level with COPD mortality (P=0.

Druh

O - Ostatní výsledky

CEP obor

FC - Pneumologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů