PROGNOSTIC SIGNIFICANCE OF SURFACTANT PROTEIN A, SURFACTANT PROTEIN D, CLARA CELL PROTEIN 16, Sioo PROTEIN, TREFOIL FACTOR 3, AND PROSTATIC SECRETORY PROTEIN 94 IN IDIOPATHIC PULMONARY FIBROSIS, SARCOIDOSIS, AND CHRONIC PULMONARY OBSTRUCTIVE DISEASE
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065787" target="_blank" >RIV/65269705:_____/16:00065787 - isvavai.cz</a>
Výsledek na webu
<a href="http://mattioli1885journals.com/index.php/sarcoidosis/article/view/4350" target="_blank" >http://mattioli1885journals.com/index.php/sarcoidosis/article/view/4350</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
PROGNOSTIC SIGNIFICANCE OF SURFACTANT PROTEIN A, SURFACTANT PROTEIN D, CLARA CELL PROTEIN 16, Sioo PROTEIN, TREFOIL FACTOR 3, AND PROSTATIC SECRETORY PROTEIN 94 IN IDIOPATHIC PULMONARY FIBROSIS, SARCOIDOSIS, AND CHRONIC PULMONARY OBSTRUCTIVE DISEASE
Popis výsledku v původním jazyce
Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.006,); 5) serum SP-A with pulmonary functions impairment in IFF (P=0.011); 6) serum SP-D level was associated with HRCT interstitial score in IPF (P=0.0346); and 7) serum SP-A was associated with staging of COPD according to spirometry (P<0.001). Moreover, our analysis showed that some biomarker levels differed significantly among the diseases: 1) BALF SP-D level differed between sarcoidosis and IPF; 2) serum SP-A level differed among IPF, sarcoidosis, COPD and was also different from healthy controls; 3) serum S100A6, S100A11 levels differed among IPF, sarcoidosis, COPD from healthy controls 4) serum SP-D, CC16, TFF-3 levels distinguished IPF patients from healthy controls; and 5) serum CC16, TFF3, PSP94 distinguished COPD patients from healthy controls. Our study shows that some of selected biomarkers should have prognostic value in the analysed lung disorders.
Název v anglickém jazyce
PROGNOSTIC SIGNIFICANCE OF SURFACTANT PROTEIN A, SURFACTANT PROTEIN D, CLARA CELL PROTEIN 16, Sioo PROTEIN, TREFOIL FACTOR 3, AND PROSTATIC SECRETORY PROTEIN 94 IN IDIOPATHIC PULMONARY FIBROSIS, SARCOIDOSIS, AND CHRONIC PULMONARY OBSTRUCTIVE DISEASE
Popis výsledku anglicky
Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.006,); 5) serum SP-A with pulmonary functions impairment in IFF (P=0.011); 6) serum SP-D level was associated with HRCT interstitial score in IPF (P=0.0346); and 7) serum SP-A was associated with staging of COPD according to spirometry (P<0.001). Moreover, our analysis showed that some biomarker levels differed significantly among the diseases: 1) BALF SP-D level differed between sarcoidosis and IPF; 2) serum SP-A level differed among IPF, sarcoidosis, COPD and was also different from healthy controls; 3) serum S100A6, S100A11 levels differed among IPF, sarcoidosis, COPD from healthy controls 4) serum SP-D, CC16, TFF-3 levels distinguished IPF patients from healthy controls; and 5) serum CC16, TFF3, PSP94 distinguished COPD patients from healthy controls. Our study shows that some of selected biomarkers should have prognostic value in the analysed lung disorders.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FC - Pneumologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Sarcoidosis vasculitis and diffuse lung diseases
ISSN
1124-0490
e-ISSN
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Svazek periodika
33
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
IT - Italská republika
Počet stran výsledku
11
Strana od-do
224-234
Kód UT WoS článku
000393274000005
EID výsledku v databázi Scopus
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