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Antimicrobial Agent Based on Selenium Nanoparticles and Carboxymethyl Cellulose for the Treatment of Bacterial Infections

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00108765" target="_blank" >RIV/00216224:14110/17:00108765 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/62156489:43210/17:43911935 RIV/00216305:26620/17:PU125347

  • Výsledek na webu

    <a href="https://doi.org/10.1166/jbn.2017.2384" target="_blank" >https://doi.org/10.1166/jbn.2017.2384</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1166/jbn.2017.2384" target="_blank" >10.1166/jbn.2017.2384</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Antimicrobial Agent Based on Selenium Nanoparticles and Carboxymethyl Cellulose for the Treatment of Bacterial Infections

  • Popis výsledku v původním jazyce

    Our main objective was to analyse and study the effects of the synthesized composite based on selenium nanoparticles and carboxymethyl cellulose (Cekol), hereinafter denoted as SeNPs-Cekol. Firstly, physico-chemical properties of SeNPs-Cekol were characterized in greater detail (size of nanoparticles-from 50 to 150 nm; content of selenium-278 ppm; pH of composite-5.4-5.6; density-990-1010 kg/m(3)), together with assessment of its stability. In addition, the toxicity and mutagenicity on prokaryotic and eukaryotic cells was successfully evaluated. All of the tested bacterial strains were isolated from wound swabs of infectious patients (n = 300) and identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). These strains were consequently exposed to SeNPs-Cekol composite. Almost all of the bacterial strains (n = 63) exhibited inhibition zones larger than 5 mm (limit for sensitivity to antibiotics) after the application of the SeNPs-Cekol (300 mu M). Furthermore, in some tested strains (n = 8 for gram positive (G(+)); n = 4 for gram negative (G(-))) even the inhibition zones larger than 12 mm (limit value for very sensitive bacteria to antibiotics) were observed. Overall, the effects of the composite were higher for the G(+) bacteria in comparison with G(-)bacteria, which are generally more resistant to antimicrobial agents, due to their cell wall structure. Further, we found that mutagenicity of the SeNPs-Cekol was found to be negligible. Even, non-target toxicity tests towards eukaryotic cells did not show any significant inhibition of the cells growth compared to the control. Therefore, it can be concluded that SeNPs-Cekol could be considered to have a potential in treatment of bacterial infections.

  • Název v anglickém jazyce

    Antimicrobial Agent Based on Selenium Nanoparticles and Carboxymethyl Cellulose for the Treatment of Bacterial Infections

  • Popis výsledku anglicky

    Our main objective was to analyse and study the effects of the synthesized composite based on selenium nanoparticles and carboxymethyl cellulose (Cekol), hereinafter denoted as SeNPs-Cekol. Firstly, physico-chemical properties of SeNPs-Cekol were characterized in greater detail (size of nanoparticles-from 50 to 150 nm; content of selenium-278 ppm; pH of composite-5.4-5.6; density-990-1010 kg/m(3)), together with assessment of its stability. In addition, the toxicity and mutagenicity on prokaryotic and eukaryotic cells was successfully evaluated. All of the tested bacterial strains were isolated from wound swabs of infectious patients (n = 300) and identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). These strains were consequently exposed to SeNPs-Cekol composite. Almost all of the bacterial strains (n = 63) exhibited inhibition zones larger than 5 mm (limit for sensitivity to antibiotics) after the application of the SeNPs-Cekol (300 mu M). Furthermore, in some tested strains (n = 8 for gram positive (G(+)); n = 4 for gram negative (G(-))) even the inhibition zones larger than 12 mm (limit value for very sensitive bacteria to antibiotics) were observed. Overall, the effects of the composite were higher for the G(+) bacteria in comparison with G(-)bacteria, which are generally more resistant to antimicrobial agents, due to their cell wall structure. Further, we found that mutagenicity of the SeNPs-Cekol was found to be negligible. Even, non-target toxicity tests towards eukaryotic cells did not show any significant inhibition of the cells growth compared to the control. Therefore, it can be concluded that SeNPs-Cekol could be considered to have a potential in treatment of bacterial infections.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Biomedical Nanotechnology

  • ISSN

    1550-7033

  • e-ISSN

  • Svazek periodika

    13

  • Číslo periodika v rámci svazku

    7

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    11

  • Strana od-do

    767-777

  • Kód UT WoS článku

    000414129200003

  • EID výsledku v databázi Scopus

    2-s2.0-85034593581