Selenium Nanoparticles and Evaluation of Their Antimicrobial Activity on Bacterial Isolates Obtained From Clinical Specimens

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43908594" target="_blank" >RIV/62156489:43210/15:43908594 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/15:PU125825

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Selenium Nanoparticles and Evaluation of Their Antimicrobial Activity on Bacterial Isolates Obtained From Clinical Specimens

Popis výsledku v původním jazyce

Our main objective was to determine the antimicrobial effects of selenium nanoparticles (SeNPs). For the testing of their influence we exploited isolates obtained from swabs from patients (n = 25) with hard-to-heal skin infections. Using mass spectrometry we identified 49 various bacterial strains. Antimicrobial properties of SeNPs were tested using measurement of inhibition zones; determination of growth curves and measurement of possible toxicity by inhibition of nucleic acid replication. Clinical isolates were exposed to the constant concentration of SeNPs (100 ?g/mL). In almost all of bacterial strains we observed inhibition zones higher than 5 mm, which are the legislatively given as the lowest value for confirmation of effectivity of tested antimicrobial agents. The most sensitive strains were further exposed to the concentration range of selenium nanoparticles (0; 1; 2; 4; 8; 16; 32 and 48 ?g/mL). Growth curves exhibited inhibition effects caused even by the lowest applied conce

Název v anglickém jazyce

Selenium Nanoparticles and Evaluation of Their Antimicrobial Activity on Bacterial Isolates Obtained From Clinical Specimens

Popis výsledku anglicky

Our main objective was to determine the antimicrobial effects of selenium nanoparticles (SeNPs). For the testing of their influence we exploited isolates obtained from swabs from patients (n = 25) with hard-to-heal skin infections. Using mass spectrometry we identified 49 various bacterial strains. Antimicrobial properties of SeNPs were tested using measurement of inhibition zones; determination of growth curves and measurement of possible toxicity by inhibition of nucleic acid replication. Clinical isolates were exposed to the constant concentration of SeNPs (100 ?g/mL). In almost all of bacterial strains we observed inhibition zones higher than 5 mm, which are the legislatively given as the lowest value for confirmation of effectivity of tested antimicrobial agents. The most sensitive strains were further exposed to the concentration range of selenium nanoparticles (0; 1; 2; 4; 8; 16; 32 and 48 ?g/mL). Growth curves exhibited inhibition effects caused even by the lowest applied conce

Druh

D - Stať ve sborníku

CEP obor

JJ - Ostatní materiály

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2015: Conference Proceedings

ISBN

978-80-87294-63-5

ISSN

—

e-ISSN

—

Počet stran výsledku

7

Strana od-do

571-577

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

14. 10. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—