SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00123444" target="_blank" >RIV/00216224:14160/21:00123444 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.faf.cuni.cz/getattachment/Special/SAL2021/Program/SAD2021_Book-of-Abstracts_v1-2.pdf.aspx?lang=en-GB" target="_blank" >https://www.faf.cuni.cz/getattachment/Special/SAL2021/Program/SAD2021_Book-of-Abstracts_v1-2.pdf.aspx?lang=en-GB</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA
Popis výsledku v původním jazyce
Recently, we have synthesized novel series of N-phenylhydroxynaphthalene carboxamides possessing promising antimicrobial activities. Introduction of alkylcarbamate moiety lead to enhancement of physical-chemical properties (especially of solubility) and the biological activity was preserved. Series of 13 novel compounds was synthesized and evaluated for antimicrobial activity. Preliminary results showed that all compounds have comparable or much better MIC than standards ciprofloxacin and ampicillin. Best compounds showed MIC in a range of few nM.
Název v anglickém jazyce
SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA
Popis výsledku anglicky
Recently, we have synthesized novel series of N-phenylhydroxynaphthalene carboxamides possessing promising antimicrobial activities. Introduction of alkylcarbamate moiety lead to enhancement of physical-chemical properties (especially of solubility) and the biological activity was preserved. Series of 13 novel compounds was synthesized and evaluated for antimicrobial activity. Preliminary results showed that all compounds have comparable or much better MIC than standards ciprofloxacin and ampicillin. Best compounds showed MIC in a range of few nM.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10401 - Organic chemistry
Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů