SYNTHESIS OF ANTIBACTERIAL CINNAMAMIDES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00131719" target="_blank" >RIV/00216224:14160/23:00131719 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

SYNTHESIS OF ANTIBACTERIAL CINNAMAMIDES

Popis výsledku v původním jazyce

Substituted N-phenyl amides of 3,4-dichlorocinnamic acid have been the subject of earlier studies. Some derivatives have shown excellent antimicrobial and antimalarial activity. The newly synthesized compounds that are the subject of this study are direct structural analogues differing in phenyl substitution. 40 derivatives with multiple substitution of both electron-donating and electron-accepting groups were synthesized and characterized, and the antimicrobial activity against Gram-positive bacteria of the genus Staphylococcus was determined. Some derivatives shown excellent activity comparable to the clinically used antibiotics ampicillin and ciprofloxacin.

Název v anglickém jazyce

SYNTHESIS OF ANTIBACTERIAL CINNAMAMIDES

Popis výsledku anglicky

Substituted N-phenyl amides of 3,4-dichlorocinnamic acid have been the subject of earlier studies. Some derivatives have shown excellent antimicrobial and antimalarial activity. The newly synthesized compounds that are the subject of this study are direct structural analogues differing in phenyl substitution. 40 derivatives with multiple substitution of both electron-donating and electron-accepting groups were synthesized and characterized, and the antimicrobial activity against Gram-positive bacteria of the genus Staphylococcus was determined. Some derivatives shown excellent activity comparable to the clinically used antibiotics ampicillin and ciprofloxacin.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů