Genotoxický potenciál toxafenu a jeho fotodegradačních produktů
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00013140" target="_blank" >RIV/00216224:14310/05:00013140 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests
Popis výsledku v původním jazyce
Toxaphene (CAS No. 800-35-2) is a complex mixture of several hundred components, that was used worldwide primarily as an agricultural pesticide with insecticide effects in the second half of the 20th century. In vitro investigations of genotoxicity and mutagenicity of toxaphene were in literature generally described, but they provided somewhat equivocal results. We re-evaluated the technical toxaphene in two prokaryotic systems. The SOS Chromotest showed high sensitivity to toxaphene. Three highest concentrations (40, 20 and 10 mg/l) were clearly positive and the dose-response effect was evident. In the umuC assay at concentrations from 2.5 to 40.0 mg/l, a dose-dependent increase in genotoxic activity was observed, but these results were found to be insignificant. Genotoxicity of toxaphene and its photodegradation products was also examined in this study after UV irradiation (3-6-9 h) at concentrations from 7.5 to 60.0 mg/l. Irradiated solution of technical toxaphene after 3 h showed n
Název v anglickém jazyce
Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests
Popis výsledku anglicky
Toxaphene (CAS No. 800-35-2) is a complex mixture of several hundred components, that was used worldwide primarily as an agricultural pesticide with insecticide effects in the second half of the 20th century. In vitro investigations of genotoxicity and mutagenicity of toxaphene were in literature generally described, but they provided somewhat equivocal results. We re-evaluated the technical toxaphene in two prokaryotic systems. The SOS Chromotest showed high sensitivity to toxaphene. Three highest concentrations (40, 20 and 10 mg/l) were clearly positive and the dose-response effect was evident. In the umuC assay at concentrations from 2.5 to 40.0 mg/l, a dose-dependent increase in genotoxic activity was observed, but these results were found to be insignificant. Genotoxicity of toxaphene and its photodegradation products was also examined in this study after UV irradiation (3-6-9 h) at concentrations from 7.5 to 60.0 mg/l. Irradiated solution of technical toxaphene after 3 h showed n
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
DN - Vliv životního prostředí na zdraví
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA525%2F03%2F0367" target="_blank" >GA525/03/0367: Ekotoxikologie persistentních organických polutantů životního prostředí</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2005
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
ISSN
1383-5718
e-ISSN
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Svazek periodika
2005
Číslo periodika v rámci svazku
565
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
113-120
Kód UT WoS článku
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EID výsledku v databázi Scopus
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