c-Myb promotes invasivity of breast cancer cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040551" target="_blank" >RIV/00216224:14310/10:00040551 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

c-Myb promotes invasivity of breast cancer cells

Popis výsledku v původním jazyce

The aim of this study was to assess the role of the c-Myb protein in control of invasivity of breast cancer cells. MDA-MB-231 breast cancer cells were transfected with the c-Myb coding cDNA to prepare MDA-MB-231MYBup derivatives. MDA-MB-231MYBup cells were significantly more active in both motility and invasion than controls as determined by Cultrex cell invasion assay. This was clearly confirmed by real-time analysis of cell migration/invasion. To address the mechanism of c-Myb-enhanced breast cancer cell invasion, we examined the role of c-Myb in control of expression and activity of some of the proteases involved in degradation of extracellular matrix. We found that c-Myb enhanced production of cathepsin D and matrix metaloproteinases in MDA-MB-231MYBup cells. These results suggest a novel role of c-Myb protein in control of tumor invasion and metastatic progression.

Název v anglickém jazyce

c-Myb promotes invasivity of breast cancer cells

Popis výsledku anglicky

The aim of this study was to assess the role of the c-Myb protein in control of invasivity of breast cancer cells. MDA-MB-231 breast cancer cells were transfected with the c-Myb coding cDNA to prepare MDA-MB-231MYBup derivatives. MDA-MB-231MYBup cells were significantly more active in both motility and invasion than controls as determined by Cultrex cell invasion assay. This was clearly confirmed by real-time analysis of cell migration/invasion. To address the mechanism of c-Myb-enhanced breast cancer cell invasion, we examined the role of c-Myb in control of expression and activity of some of the proteases involved in degradation of extracellular matrix. We found that c-Myb enhanced production of cathepsin D and matrix metaloproteinases in MDA-MB-231MYBup cells. These results suggest a novel role of c-Myb protein in control of tumor invasion and metastatic progression.

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů