Cystatins of the parasitic nematodes from the genus Trichinella

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cystatins of the parasitic nematodes from the genus Trichinella

Popis výsledku v původním jazyce

The nematodes of the genus Trichinella are intracellular parasites of small intestine and skeletal muscle cells. They can infect a broad range of worldwide distributed hosts like birds, reptiles and mammals. All Trichinella spp. are zoonotic but only sixof twelve genotypes have been detected in humans, causing the trichinellosis - a serious, sometimes fatal, human disease, which has been documented in 55 countries of the World. Our study is focused on characterization of composition of excretory-secretory products (ESP) from L1 muscle larvae of three trichinella species - Trichinella spiralis, T. britovi and T. pseudospiralis. The dominant components of L1 ESP are cystatins. These proteins are a reversible inhibitors of proteolytics enzymes - cysteinpeptideases and they are involved in many relevant biological processes such as development, growth, digestion and migration of parasites and suppression of host immune responses.

Název v anglickém jazyce

Cystatins of the parasitic nematodes from the genus Trichinella

Popis výsledku anglicky

The nematodes of the genus Trichinella are intracellular parasites of small intestine and skeletal muscle cells. They can infect a broad range of worldwide distributed hosts like birds, reptiles and mammals. All Trichinella spp. are zoonotic but only sixof twelve genotypes have been detected in humans, causing the trichinellosis - a serious, sometimes fatal, human disease, which has been documented in 55 countries of the World. Our study is focused on characterization of composition of excretory-secretory products (ESP) from L1 muscle larvae of three trichinella species - Trichinella spiralis, T. britovi and T. pseudospiralis. The dominant components of L1 ESP are cystatins. These proteins are a reversible inhibitors of proteolytics enzymes - cysteinpeptideases and they are involved in many relevant biological processes such as development, growth, digestion and migration of parasites and suppression of host immune responses.

Druh

O - Ostatní výsledky

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů