CD36 AA single nucleotide polymorphism (SNP) is associated with decreased lipid taste perception in Tunisian obese women: association with pro-inflammatory TNF-a GA and IL-6 GC genotypes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00083198" target="_blank" >RIV/00216224:14310/14:00083198 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1111/fcp.12064" target="_blank" >http://dx.doi.org/10.1111/fcp.12064</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/fcp.12064" target="_blank" >10.1111/fcp.12064</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
CD36 AA single nucleotide polymorphism (SNP) is associated with decreased lipid taste perception in Tunisian obese women: association with pro-inflammatory TNF-a GA and IL-6 GC genotypes
Popis výsledku v původním jazyce
We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-a (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-a gene polymorphisms.
Název v anglickém jazyce
CD36 AA single nucleotide polymorphism (SNP) is associated with decreased lipid taste perception in Tunisian obese women: association with pro-inflammatory TNF-a GA and IL-6 GC genotypes
Popis výsledku anglicky
We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-a (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-a gene polymorphisms.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
CE - Biochemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů